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Cat. No.: HY-187935

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E-0702

E-0702 is a cephalosporin antibacterial compound containing a catechol moiety. E-0702 chelates ferric ions, enters the intracellular compartment of Gram-negative bacteria via the TonB-dependent iron uptake system, and exerts bactericidal effects by inhibiting penicillin-binding proteins (PBPs). E-0702 exhibits iron-regulated bactericidal activity against Gram-negative bacteria and some Gram-positive bacteria, and possesses broad-spectrum anti-Pseudomonas activity. E-0702 can be hydrolyzed by common β-lactamases. E-0702 can be used in research related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 77768-46-8
Formula: C₂₉H₂₃N₇O₁₂S₂
Molecular Weight:725.66

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Please store the product under the recommended conditions in the Certificate of Analysis.

E-0702 Chemical Structure

CAS No.: 77768-46-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

All Beta-lactamase Isoforms :

In Vitro

Bacterial Infection

E-0702 is a cephalosporin with activity against Pseudomonas aeruginosa; it acts as an iron chelator and enters Escherichia coli via the tonB-dependent iron transport system, exerting rapid bactericidal action when iron is scarce and the iron transport system is induced, and its resistance mutations are caused by tonB mutations^[1]^[3].
E‑0702 is a novel cephalosporin that is hydrolyzed by plasmid-mediated β‑lactamases, shows weak inhibition against plasmid and chromosomal β‑lactamases, and exhibits an inoculum effect^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 77768-46-8
Molecular Weight 725.66
Formula C₂₉H₂₃N₇O₁₂S₂
SMILES

OC(C1=C(CSC2=NN=NN2CC(O)=O)CS[C@@]([C@@H]3NC([C@@H](C4=CC=C(C=C4)O)NC(C(C(C5=C6)=O)=COC5=CC(O)=C6O)=O)=O)([H])N1C3=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lin YM, et al. Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2019 Jun;32(3):425-451.

[2]. Neu HC. In vitro antibacterial activity and beta-lactamase stability of E-0702, a new cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):313-20.

[3]. Watanabe NA, et al. E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the tonB-dependent iron transport system. Antimicrobial agents and chemotherapy. 1987 Apr;31(4):497-504.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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E-0702

All Beta-lactamase Isoforms

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E-0702

All Beta-lactamase Isoforms

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