Methiocarb
Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals.
For research use only. We do not sell to patients.
- CAS No.: 2032-65-7
- Formula: C11H15NO2S
- Molecular Weight:225.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Methiocarb (2.5-7.5 mg/L; 72 h) exerts dose-dependent toxic effects on Allium cepa L. bulbs, including reducing rooting rate, root length and weight gain rate, increasing micronucleus rate, chromosome damage degree and MDA level, decreasing mitotic index, and elevating SOD and CAT activities, with the strongest effects observed at the concentration of 7.5 mg/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar Albino (male, 12-13 weeks old, 160 ± 20 g)[2]
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Dosage:25 mg/kg (1-day treatment); 10 mg/kg (5-day treatment); 2 mg/kg (28-day treatment)
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Administration:i.g.; once (1-day); daily (5-day, 28-day)
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Result:Increased LPO in the liver, kidney, brain and testis after 1, 5 and 28 days treatment, with the most significant increase in the brain.
Significantly elevated GSH levels in all the above tissues after 1 day of treatment but significantly decreased after 5 and 28 days of treatment, and the decrease in GSH levels in the kidney, brain and testis was more pronounced than that in the liver.
Chemical Information
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CAS No. 2032-65-7
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Molecular Weight 225.31
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Formula C11H15NO2S
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SMILES
O=C(NC)OC1=CC(C)=C(SC)C(C)=C1
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Synonyms
Mercaptodimethur
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Methiocarb Related Classifications
HY-124920 Related Classifications
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