MGD010
Based on 1 Customer Validation
MGD010 (PRV-3279) is a bispecific antibody targeting CD32B (FcγRIIb) and CD79B. MGD010 transmits negative signals by simultaneously co-linking CD32B (FcγRIIb) with CD79B, a component of the B-cell receptor (BCR), thereby inhibiting activated B cells. MGD010 can be used in research related to autoimmune diseases.
For research use only. We do not sell to patients.
- Purity : 99.06%
- Molecular Weight:108.77 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD79b & Fc-gamma-R2B
In Vitro
MGD010 specifically binds to two key molecules on the surface of B cells simultaneously: CD32B and CD79B, thereby inhibiting the function of activated B cells without depleting them[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Human CD79B Protein, His Tag can bind MGD010. The EC50 for this effect is 230.9 ng/mL. -
Loaded MGD010 on ProA biosensor, can bind Human CD32b/c Protein, His Tag with an affinity constant of 1.15E-08 M as determined in BLI assay.
Chemical Information
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Appearance Liquid
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Molecular Weight 108.77 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
PRV-3279
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)