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Cat. No.: HY-107603

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NS3763

NS3763 is a selective and noncompetitive GLU_K5 receptor antagonist with an IC₅₀ of 1.6 µM. NS3763 does not show significant antagonistic properties on GLU_K6, AMPA or NMDA receptors.

For research use only. We do not sell to patients.

CAS No.: 70553-45-6
Formula: C₂₂H₁₆N₂O₆
Molecular Weight:404.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NS3763 Chemical Structure

CAS No.: 70553-45-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

NS3763 is a selective and noncompetitive GLU_K5 receptor antagonist with an IC₅₀ of 1.6 µM. NS3763 does not show significant antagonistic properties on GLU_K6, AMPA or NMDA receptors^[1].

IC₅₀ & Target

IC50: 1.6 µM (GLU_K5 receptor)^[1]

All iGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1.6 μM Compound: NS-3763	In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells. In vitro inhibitory activity against human ionotropic glutamate receptor ionotropic kainate 1 (GluR-5) expressed in HEK293 cells.	[PMID: 14667236]

In Vitro

In human embryonic kidney HEK293 cells expressing homomeric GLU_K5 or GLU_K6 receptors, NS3763 displays selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLUK5 subtype (IC₅₀ = 1.6 µM) of kainate receptors compared with the GLUK6 subtype (IC₅₀ > 30 µM)^[1].
NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLU_K5 receptors in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 70553-45-6
Molecular Weight 404.37
Formula C₂₂H₁₆N₂O₆
SMILES

O=C(C1=C(NC(C2=CC=CC=C2)=O)C=C(NC(C3=CC=CC=C3)=O)C(C(O)=O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jeppe K Christensen, et al. In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J Pharmacol Exp Ther. 2004 Jun;309(3):1003-10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NS3763

All iGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NS3763 Related Classifications

HY-107603 Related Classifications