SGX393
SGX393 (SGX70393) is a Bcr-Abl kinase inhibitor. SGX393 binds to the active conformation of the kinase domains of both wild-type and T315I mutant Bcr-Abl, thereby inhibiting kinase activity. SGX393 exhibits antiproliferative effects in cells expressing wild-type or T315I mutant Bcr-Abl, and suppresses T315I-driven tumor growth. SGX393 can be used for the research of chronic myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 1030610-86-6
- Formula: C21H22N6O
- Molecular Weight:374.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SGX393 potently inhibits the proliferation of Ba/F3 cells expressing WT Bcr-Abl (IC50 = 12 nM) and Bcr-AblT315I (IC50 = 7.3 nM), while being inactive against parental Ba/F3 cells[1].
SGX393 inhibits Bcr-Abl kinase activity in primary CML cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1030610-86-6
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Molecular Weight 374.45
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Formula C21H22N6O
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SMILES
O=C(C=1C=C(C=CC1N)C2=CN=C3NC=C(C3=C2)C4=CC=NN4CC)N(C)C
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Synonyms
SGX70393
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SGX393 Related Classifications
HY-165532 Related Classifications
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