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Sivelestat

(Synonyms: EI546; LY544349; ONO5046)
31 Cited Publications
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Based on 31 publication(s) in Google Scholar

Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

For research use only. We do not sell to patients.

  • Purity: 99.68%
  • CAS No.: 127373-66-4
  • Formula: C20H22N2O7S
  • Molecular Weight:434.46
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Sivelestat Chemical Structure
    Sivelestat Chemical Structure
  • Experimental Validation Results for Sivelestat
  • Experimental Validation Results for Sivelestat
  • Experimental Validation Results for Sivelestat
  • Experimental Validation Results for Sivelestat
  • Experimental Validation Results for Sivelestat
CAS No.: 127373-66-4
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Flow CytometryIn Vivo Efficacy StudyIn Vivo Imaging
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  • Sivelestat Chemical Structure
    Sivelestat Chemical Structure
    1/16
  • 1/16

    Sivelestat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 5;16(1):1378. [Abstract]

    Customer Validation
     To evaluate this specific effect of NETosis in the Brd7-deficient context, we treated the mice injected with Brd7-KO cells with either Sivelestat (50 mg/kg) or DMSO starting at the 2-week timepoint, which marks the onset of lung metastatic outgrowth. FACS analysis of dissociated lungs isolated at the 4-week timepoint demonstrated a significant decrease in CTLA4 + CD8 + and PD1 + CD8 + T cells upon Sivelestat treatment.

  • 1/16

    Sivelestat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 5;16(1):1378. [Abstract]

    Customer Validation
     To evaluate this specific effect of NETosis in the Brd7-deficient context, we treated the mice injected with Brd7-KO cells with either Sivelestat (50 mg/kg) or DMSO starting at the 2-week timepoint, which marks the onset of lung metastatic outgrowth.

  • 1/16

    Sivelestat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 5;16(1):1378. [Abstract]

    Customer Validation
     The mice injected with the 4T07-TGL-Brd7 KO cells (Day 0) were i.p. injected with Sivelestat (50 mg/kg) or DMSO control on days -5,-3,-1,1 and on every alternate day thereafter until Week 4. Represent bioluminescence images for the indicated murine cohorts at 30 min, 1 week, and 4 weeks post tumor cell injection.

  • 1/16

    Sivelestat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 5;16(1):1378. [Abstract]

    Customer Validation
     The mice injected with the 4T07-TGL-Brd7 KO cells (Day 0) were i.p. injected with Sivelestat (50 mg/kg) or DMSO control on days -5,-3,-1,1 and on every alternate day thereafter until Week 4. Line graph showing the normalized photon flux for the indicated murine cohorts over time.

  • 1/16

    Sivelestat purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Sep;57(9):2067-2082. [Abstract]

    Customer Validation
     Sivelestat treatment selectively modulates innate immune cell populations in lung and spleen. Data on weight change in the untreated group (infected with SARS-CoV-2 only) and the Sivelestat (10 mg/kg/day, 50 μL, intraperitoneally)/2% DMSO saline treatment group.

  • Sivelestat