SM311
Based on 1 Customer Validation
SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion.
For research use only. We do not sell to patients.
- Purity : 98.68%
- Formula: C20H19F2N5O2S
- Molecular Weight:431.46
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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LIMK1 0.045 μM (EC50) |
LIMK2 |
Chemical Information
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Appearance Solid
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Molecular Weight 431.46
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Formula C20H19F2N5O2S
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Color White to off-white
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SMILES
FC(F)C1=NN(C2=CC=C(NC(C=C)=O)C=C2)C(C3=CN=C(NC(C(C)C)=O)S3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (231.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3177 mL | 11.5886 mL | 23.1771 mL | 57.9428 mL |
| 5 mM | 0.4635 mL | 2.3177 mL | 4.6354 mL | 11.5886 mL | |
| 10 mM | 0.2318 mL | 1.1589 mL | 2.3177 mL | 5.7943 mL | |
| 15 mM | 0.1545 mL | 0.7726 mL | 1.5451 mL | 3.8629 mL | |
| 20 mM | 0.1159 mL | 0.5794 mL | 1.1589 mL | 2.8971 mL | |
| 25 mM | 0.0927 mL | 0.4635 mL | 0.9271 mL | 2.3177 mL | |
| 30 mM | 0.0773 mL | 0.3863 mL | 0.7726 mL | 1.9314 mL | |
| 40 mM | 0.0579 mL | 0.2897 mL | 0.5794 mL | 1.4486 mL | |
| 50 mM | 0.0464 mL | 0.2318 mL | 0.4635 mL | 1.1589 mL | |
| 60 mM | 0.0386 mL | 0.1931 mL | 0.3863 mL | 0.9657 mL | |
| 80 mM | 0.0290 mL | 0.1449 mL | 0.2897 mL | 0.7243 mL | |
| 100 mM | 0.0232 mL | 0.1159 mL | 0.2318 mL | 0.5794 mL |
SM311 Related Classifications
HY-174229 Related Classifications
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