Noladin ether

Cat. No.: HY-110014: Data Sheet
COA

SDS
Handling Instructions
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Noladin ether is a potent and selective agonist of cannabinoid CB₁ receptor, with a K_i of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception.

For research use only. We do not sell to patients.

CAS No. : 222723-55-9

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This product is a controlled substance and not for sale in your territory.

1 Publications Citing Use of MCE Noladin ether

•J Headache Pain. 2023 Apr 21;24(1):44. [Abstract]

: Noladin ether purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2023 Apr 21;24(1):44. [Abstract]; ZD 7288 (5 μg; i.c.) robustly reduced the number of c-Fos-positive cells and the average fluorescence intensity of CGRP and SP in CM mice.

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CB1 CB2

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Purity & Documentation
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Description

Noladin ether is a potent and selective agonist of cannabinoid CB₁ receptor, with a K_i of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception^[1].

IC₅₀ & Target^[1]

CB1

21.2 nM (Ki)

CB2

>3 mM (Ki)

Molecular Weight

364.56

Formula

C₂₃H₄₀O₃

CAS No.

222723-55-9

Appearance

Liquid (Density: 0.948±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CO)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (261 KB) SDS (545 KB)

COA (237 KB)

Handling Instructions (2659 KB)

References

[1]. Hanus L, et, al. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3662-5. [Content Brief]

Noladin ether Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Noladin ether222723-55-9Cannabinoid Receptorhypothermiaintestinal immobilityInhibitorinhibitorinhibit

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