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Cat. No.: HY-110014

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Noladin ether

1 Cited Publications

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Noladin ether is a potent and selective agonist of cannabinoid CB₁ receptor, with a K_i of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception.

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CAS No.: 222723-55-9
Formule: C₂₃H₄₀O₃
Masse moléculaire:364.56

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4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Noladin ether Chemical Structure

CAS No.: 222723-55-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Noladin ether is a potent and selective agonist of cannabinoid CB₁ receptor, with a K_i of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception^[1].

IC₅₀ & Target^[1]

CB1

21.2 nM (Ki)

CB2

>3 mM (Ki)

Voir tous les produits spécifiques à Isoform Cannabinoid Receptor :

Chemical Information

CAS No. 222723-55-9
Appearance Liquid (Density: 0.948±0.06 g/cm³)
Masse moléculaire 364.56
Formule C₂₃H₄₀O₃
Color Colorless to light yellow
SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CO)CO
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Publications (1)

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J Headache Pain

Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model. [Abstract]

2023 Apr 21;24(1):44. PMID: 37085778

Noladin ether purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2023 Apr 21;24(1):44. [Abstract]

ZD 7288 (5 μg; i.c.) robustly reduced the number of c-Fos-positive cells and the average fluorescence intensity of CGRP and SP in CM mice.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (261 KB)
SDS (545 KB)
- English - EN (545 KB)
- Français - FR (545 KB)
- Deutsch - DE (545 KB)
- Norwegian - NO (545 KB)
- Español - ES (545 KB)
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- Italian - IT (545 KB)
- Korean - KR (545 KB)
- Portuguese - PT (545 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hanus L, et, al. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3662-5. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Noladin ether

1 Cited Publications

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Noladin ether purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2023 Apr 21;24(1):44. [Abstract]

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ZD 7288 (5 μg; i.c.) robustly reduced the number of c-Fos-positive cells and the average fluorescence intensity of CGRP and SP in CM mice.

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Noladin ether

Publications Citing Use of MedChemExpress (MCE) Noladin ether

Voir tous les produits spécifiques à Isoform Cannabinoid Receptor

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Publications (1)

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Noladin ether Related Classifications

HY-110014 Related Classifications