Noladin ether
Based on 1 publication(s) in Google Scholar
Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 222723-55-9
- 分子式: C23H40O3
- 分子量:364.56
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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生物活性
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化学情報
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MedChemExpress（MCE）の使用を引用している文献 Noladin ether
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Customer Validation & Images
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IF
生物活性
製品説明
IC50 & Target
[1]|
CB1 21.2 nM (Ki) |
CB2 >3 mM (Ki) |
化学情報
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CAS 番号 222723-55-9
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性状 Liquid (Density: 0.948±0.06 g/cm3)
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分子量 364.56
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分子式 C23H40O3
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Color Colorless to light yellow
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SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCOC(CO)CO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Headache Pain
Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model. [Abstract]2023 Apr 21;24(1):44. PMID: 37085778
Noladin ether purchased from MedChemExpress. Usage Cited in: J Headache Pain. 2023 Apr 21;24(1):44. [Abstract]
ZD 7288 (5 μg; i.c.) robustly reduced the number of c-Fos-positive cells and the average fluorescence intensity of CGRP and SP in CM mice.
プロトコル
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Formalin-Induced Paw Inflammation/Nociceptive Inflammation
The formalin-induced paw inflammation/nociceptive test is a chemical persistent pain model in rodents in which subcutaneous injection of formalin into the hind paw produces spontaneous nocifensive behaviors such as flinching and licking. The response is classically biphasic, consisting of an early acute phase (Phase I) reflecting direct activation of peripheral nociceptors (particularly C-fiber afferents), followed by a later prolonged phase (Phase II) associated with central sensitization in the spinal dorsal horn driven by sustained afferent input and inflammatory signaling. This model is widely used to evaluate analgesic and anti-inflammatory interventions because it captures both peripheral nociception and central sensitization processes within a single assay system.
純度とドキュメンテーション
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データシート (261 KB)
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SDS (545 KB)
- English - EN (545 KB)
- Français - FR (545 KB)
- Deutsch - DE (545 KB)
- Norwegian - NO (545 KB)
- Español - ES (545 KB)
- Swedish - SV (545 KB)
- Italian - IT (545 KB)
- Korean - KR (545 KB)
- Portuguese - PT (545 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Noladin ether 関連分類
HY-110014 関連分類
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