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Cat. No.: HY-183237

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Oxphaman

Oxphaman is a pea lipoxygenase inhibitor with an IC₅₀ of 140 nM against pea lipoxygenase. Oxphaman inhibits protamine sulfate-induced degranulation of rat peritoneal mast cells.

For research use only. We do not sell to patients.

CAS No.: 112851-89-5
Formula: C₁₇H₂₁NO₂
Molecular Weight:271.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Oxphaman Chemical Structure

CAS No.: 112851-89-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Oxphaman is a pea lipoxygenase inhibitor with an IC₅₀ of 140 nM against pea lipoxygenase. Oxphaman inhibits protamine sulfate-induced degranulation of rat peritoneal mast cells^[1].

IC₅₀ & Target

^[1]

lipoxygenase

140 nM (IC₅₀)

All Lipoxygenase Isoforms :

In Vitro

Oxphaman (ZIMET 47/79) inhibits purified pea lipoxygenase activity with an IC₅₀ of 1.4×10^-4 mol/L^[1].
Oxphaman (5 minutes prior to protamine sulfate activation) inhibits protamine sulfate-induced degranulation of peritoneal rat mast cells with an IC₅₀ of 3.4×10^-5 mol/L^[1].
Oxphaman (2.5×10^-4-5×10^-4 mol/L; 5 minutes prior to Triton X-100 activation) weakly inhibits Triton X-100-induced degranulation of peritoneal rat mast cells, with 26.0% inhibition at 5×10^-4 mol/L and 13.9% inhibition at 2.5×10^-4 mol/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 112851-89-5
Molecular Weight 271.35
Formula C₁₇H₂₁NO₂
SMILES

OC1=CC=C(C(/C=N/C23CC4CC(C3)CC(C2)C4)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bahr T, et al. Lipoxygenase-inhibitory azomethines and benzoylhydrazones. I. Inhibition of the lipoxygenase activity and of the degranulation of mast cells in vitro by phenolic azomethines. Agents Actions. 1991 Jan;32(1-2):137-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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