PD-168077
Based on 1 publication(s) in Google Scholar
PD-168077 is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
For research use only. We do not sell to patients.
- CAS No.: 190383-31-4
- Formula: C20H22N4O
- Molecular Weight:334.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) PD-168077
MoreAll Dopamine Receptor Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
17 nM
Compound: 6
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Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
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[PMID: 9191952] |
| HEK293 | EC50 |
>10 μM
Compound: 2
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Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
| HEK293 | EC50 |
8.3 nM
Compound: 2
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Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay
Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
| HEK293 | EC50 |
8.3 nM
Compound: 2, PD-168077
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Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR
Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR
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[PMID: 17149874] |
| HEK293 | IC50 |
>10 μM
Compound: 2
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Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assay
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[PMID: 16913699] |
In Vitro
In the PD-168077-treated cell, p-CaMKII exhibits a significantly increased clustering at synaptic sites, as indicated by the enhanced colocalization with PSD-95[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 190383-31-4
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Molecular Weight 334.41
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Formula C20H22N4O
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SMILES
O=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22(5):538-44. [Content Brief]
[2]. Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69(3):813-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-168077 Related Classifications
HY-21098 Related Classifications
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