Pebezertinib
Based on 1 Customer Validation
Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS). Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.56%
- CAS 番号: 2769954-39-2
- 分子式: C24H19F4N7O
- 分子量:497.45
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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EGFR アイソフォーム固有の製品をすべて表示
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生物活性
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2769954-39-2
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性状 Solid
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分子量 497.45
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分子式 C24H19F4N7O
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Color White to off-white
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SMILES
O=C(NC1=CC=C(C(NC2=C(C3=CC=C(C(F)(F)F)C=C3)C=NC(NC4=CN(C)N=C4)=N2)=C1)F)C=C
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別名
BLU 451; LNG-451
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 116.67 mg/mL (234.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0103 mL | 10.0513 mL | 20.1025 mL | 50.2563 mL |
| 5 mM | 0.4021 mL | 2.0103 mL | 4.0205 mL | 10.0513 mL | |
| 10 mM | 0.2010 mL | 1.0051 mL | 2.0103 mL | 5.0256 mL | |
| 15 mM | 0.1340 mL | 0.6701 mL | 1.3402 mL | 3.3504 mL | |
| 20 mM | 0.1005 mL | 0.5026 mL | 1.0051 mL | 2.5128 mL | |
| 25 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 2.0103 mL | |
| 30 mM | 0.0670 mL | 0.3350 mL | 0.6701 mL | 1.6752 mL | |
| 40 mM | 0.0503 mL | 0.2513 mL | 0.5026 mL | 1.2564 mL | |
| 50 mM | 0.0402 mL | 0.2010 mL | 0.4021 mL | 1.0051 mL | |
| 60 mM | 0.0335 mL | 0.1675 mL | 0.3350 mL | 0.8376 mL | |
| 80 mM | 0.0251 mL | 0.1256 mL | 0.2513 mL | 0.6282 mL | |
| 100 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5026 mL |
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