2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Peucedanol

Peucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively.

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Peucedanol Chemical Structure

Peucedanol Chemical Structure

CAS No. : 46992-81-8

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Peucedanol Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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Description

Peucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively[1].

In Vitro

Peucedanol (0, 2.5, 5, 10, 25, 50, and 100 μM; 0-30 min) is incubated with eight human liver CYP isoforms (CYP1A2, 2A6, 3A4, 2C8, 2C9, 2C19, 2D6, and 2E1), in pooled human liver microsomes (HLMs) for 30 min with specific inhibitors as positive controls.Peucedanol significantly inhibits the activity of CYP1A2, 2D6, and 3A4 in a dose-dependent manner with IC50 values of 6.03 μM, 13.57 μM, and 7.58 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peucedanol Related Antibodies
Molecular Weight

264.27

Formula

C14H16O5
CAS No.
SMILES

O=C1OC2=C(C=C1)C=C(CC(C(C)(C)O)O)C(O)=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Peucedanol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peucedanol46992-81-8Cytochrome P450CYPsCYP3A4CYP1A2CYP2D6Inhibitorinhibitorinhibit

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