2. Metabolic Enzyme/Protease
  3. Glucokinase
  4. Nerigliatin

Nerigliatin  (Synonyms: PF-04937319)

Cat. No.: HY-108328 Purity: 99.78%
COA Handling Instructions

Nerigliatin (PF-04937319) is a glucokinase activator (GKA) with EC50 value of 154.4 ?μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus. Nerigliatin is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs.

For research use only. We do not sell to patients.

Nerigliatin Chemical Structure

Nerigliatin Chemical Structure

CAS No. : 1245603-92-2

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 121 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 121 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 190 In-stock
25 mg USD 390 In-stock
50 mg USD 710 In-stock
100 mg USD 1280 In-stock
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Based on 1 publication(s) in Google Scholar

Nerigliatin Related Antibodies

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Description

Nerigliatin (PF-04937319) is a glucokinase activator (GKA) with EC50 value of 154.4 ?μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus[1]. Nerigliatin is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs[2].

IC50 & Target

EC50: 154.4 μM (GSA) (PF-04937319)[1]
Clinical Trial
Molecular Weight

432.43

Appearance

Solid

Formula

C22H20N6O4
CAS No.
SMILES

O=C(C1=NC=C(OC2=C3C=C(C)OC3=CC(C(NC4=NC=C(C)N=C4)=O)=C2)C=N1)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (231.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3125 mL 11.5626 mL 23.1251 mL
5 mM 0.4625 mL 2.3125 mL 4.6250 mL
10 mM 0.2313 mL 1.1563 mL 2.3125 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.78%

COA (254 KB) HNMR (130 KB) LCMS (235 KB)

Handling Instructions (2659 KB)
References
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Nerigliatin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Nerigliatin1245603-92-2PF-04937319PF04937319PF 04937319GlucokinaseHexokinase IVHexokinase DInhibitorinhibitorinhibit

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