country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-184581

Copy Link Print Information

Pomalidomide-5-C4-acid

Pomalidomide-5-C4-acid is an E3 ligase ligand-linker conjugate that can be used for PROTAC synthesis, such as PROTAC BRAF-V600E degrader-2 (HY-137488).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2412056-33-6
Fòrmula: C₁₈H₁₉N₃O₆
Peso molecular:373.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pomalidomide-5-C4-acid Chemical Structure

No. CAS: 2412056-33-6

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Pomalidomide-5-C4-acid is an E3 ligase ligand-linker conjugate that can be used for PROTAC synthesis, such as PROTAC BRAF-V600E degrader-2 (HY-137488)^[1].

Ver todos los productos específicos de isoformas E3 Ligase Ligand-Linker Conjugates :

In Vitro

Pomalidomide-5-C4-acid can be used in the synthesis of PROTAC BRAF-V600E degrader-2 (HY-137488), which is a BRAF-V600E degrader with K_d values of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 inhibits the growth of melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2412056-33-6
Peso molecular 373.36
Fòrmula C₁₈H₁₉N₃O₆
SMILES

O=C(O)CCCCNC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Han XR, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. Journal of medicinal chemistry. 2020 Apr 23;63(8):4069-4080. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Pomalidomide-5-C4-acid

100 mg Obtener un presupuesto

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

Pomalidomide-5-C4-acid

Ver todos los productos específicos de isoformas E3 Ligase Ligand-Linker Conjugates

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Pomalidomide-5-C4-acid Related Classifications

HY-184581 Related Classifications