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Cat. No.: HY-184581

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Pomalidomide-5-C4-acid

Pomalidomide-5-C4-acid is an E3 ligase ligand-linker conjugate that can be used for PROTAC synthesis, such as PROTAC BRAF-V600E degrader-2 (HY-137488).

For research use only. We do not sell to patients.

CAS No.: 2412056-33-6
Formula: C₁₈H₁₉N₃O₆
Molecular Weight:373.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pomalidomide-5-C4-acid Chemical Structure

CAS No.: 2412056-33-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

Pomalidomide-5-C4-acid is an E3 ligase ligand-linker conjugate that can be used for PROTAC synthesis, such as PROTAC BRAF-V600E degrader-2 (HY-137488)^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

Pomalidomide-5-C4-acid can be used in the synthesis of PROTAC BRAF-V600E degrader-2 (HY-137488), which is a BRAF-V600E degrader with K_d values of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 inhibits the growth of melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2412056-33-6
Molecular Weight 373.36
Formula C₁₈H₁₉N₃O₆
SMILES

O=C(O)CCCCNC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Han XR, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. Journal of medicinal chemistry. 2020 Apr 23;63(8):4069-4080. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Pomalidomide-5-C4-acid

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Pomalidomide-5-C4-acid Related Classifications

HY-184581 Related Classifications