2. Immunology/Inflammation Apoptosis
  3. NO Synthase TNF Receptor Interleukin Related
  4. Poricoic acid B

Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases[3].

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Poricoic acid B

Poricoic acid B Estructura química

No. CAS : 137551-39-4

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Poricoic acid B Related Antibodies

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Descripciòn

Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases[1][2][3].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
> 100 μM
Compound: 10
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 19746919]
In Vitro

Poricoic acid B (25-100 μM; 24 h) inhibits lipid accumulation in fat emulsion-induced steatotic L-02 hepatocytes and reduces the levels of hepatocyte injury markers[1].
Poricoic acid B (0-40 μg/mL; 24 h) inhibits LPS (HY-D1056)-induced NO production in RAW 264.7 cells and reduces the secretion of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Poricoic acid B Related Antibodies

ELISA Assay[3]

Cell Line: LPS-induced RAW 264.7 mouse macrophage cells
Concentration: 10, 20, 40 μg/mL
Incubation Time: 24 h (co-incubated with LPS)
Result: Decreased TNF-α secretion significantly across all concentrations, with the lowest level at 20 μg/mL (32% reduction compared to the LPS-treated group).
Showed no significant difference in IL-1β secretion at 10 μg/mL; reduced IL-1β secretion by 41% at 20 μg/mL and 77% at 40 μg/mL compared to the LPS-treated group.
Reduced IL-6 secretion by 30%, 53%, and 66% at 10, 20, and 40 μg/mL respectively, compared to the LPS-treated group.
Peso molecular

484.67

Fòrmula

C30H44O5
No. CAS
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)CC[C@@]1(C)[C@H](C(C)=C)CC=C2[C@]3(C)C[C@@H](O)[C@H]([C@H](C(O)=O)CC/C=C(C)\C)[C@@]3(C)CC=C21
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 250 mg/mL (515.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0633 mL 10.3163 mL 20.6326 mL
5 mM 0.4127 mL 2.0633 mL 4.1265 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0633 mL 10.3163 mL 20.6326 mL 51.5815 mL
5 mM 0.4127 mL 2.0633 mL 4.1265 mL 10.3163 mL
10 mM 0.2063 mL 1.0316 mL 2.0633 mL 5.1581 mL
15 mM 0.1376 mL 0.6878 mL 1.3755 mL 3.4388 mL
20 mM 0.1032 mL 0.5158 mL 1.0316 mL 2.5791 mL
25 mM 0.0825 mL 0.4127 mL 0.8253 mL 2.0633 mL
30 mM 0.0688 mL 0.3439 mL 0.6878 mL 1.7194 mL
40 mM 0.0516 mL 0.2579 mL 0.5158 mL 1.2895 mL
50 mM 0.0413 mL 0.2063 mL 0.4127 mL 1.0316 mL
60 mM 0.0344 mL 0.1719 mL 0.3439 mL 0.8597 mL
80 mM 0.0258 mL 0.1290 mL 0.2579 mL 0.6448 mL
100 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.5158 mL
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Poricoic acid B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poricoic acid B137551-39-4NO SynthaseTNF ReceptorInterleukin RelatedNitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRILtriterpenoid compoundL-02 hepatocytesRAW 264.7 cellsInhibitorinhibitorinhibit

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Poricoic acid B
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HY-N4124
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