PPARα/γ agonist 1

Cat. No.: HY-143239 Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist with EC₅₀ values of 28 nM and 69 nM for PPARα and PPARγ, respectively. PPARα/γ agonist 1 is a promising prototype for dyslipidemia and diabetes research.

For research use only. We do not sell to patients.

PPARα/γ agonist 1 Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 82	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 132	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 265	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 425	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

PPARα

28 nM (EC₅₀)

PPARγ

69 nM (EC₅₀)

Molecular Weight

281.35

Formula

C₁₈H₁₉NO₂

Appearance

Solid

Color

White to off-white

SMILES

CC(OC1=CC=C(C=C1)/C=C/C2=CC=CC=C2)(C(N)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (355.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5543 mL	17.7715 mL	35.5429 mL
5 mM	0.7109 mL	3.5543 mL	7.1086 mL
10 mM	0.3554 mL	1.7771 mL	3.5543 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (246 KB) HNMR (226 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Luiz A Dutra, et al. Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice. Bioorg Chem. 2 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5543 mL	17.7715 mL	35.5429 mL	88.8573 mL
	5 mM	0.7109 mL	3.5543 mL	7.1086 mL	17.7715 mL
	10 mM	0.3554 mL	1.7771 mL	3.5543 mL	8.8857 mL
	15 mM	0.2370 mL	1.1848 mL	2.3695 mL	5.9238 mL
	20 mM	0.1777 mL	0.8886 mL	1.7771 mL	4.4429 mL
	25 mM	0.1422 mL	0.7109 mL	1.4217 mL	3.5543 mL
	30 mM	0.1185 mL	0.5924 mL	1.1848 mL	2.9619 mL
	40 mM	0.0889 mL	0.4443 mL	0.8886 mL	2.2214 mL
	50 mM	0.0711 mL	0.3554 mL	0.7109 mL	1.7771 mL
	60 mM	0.0592 mL	0.2962 mL	0.5924 mL	1.4810 mL
	80 mM	0.0444 mL	0.2221 mL	0.4443 mL	1.1107 mL
	100 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.8886 mL