PROTAC ERα Y537S degrader-1
PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 extracts from patent WO2021143822, example 12. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader.
For research use only. We do not sell to patients.
- CAS No.: 2667598-05-0
- Formula: C46H49N5O6
- Molecular Weight:767.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Description
Chemical Information
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CAS No. 2667598-05-0
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Molecular Weight 767.91
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Formula C46H49N5O6
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SMILES
O=C1C2=C(CN1C3C(NC(CC3)=O)=O)C=C(N4CCN(CC4)CC5CCN(C6=CC=C([C@]7([H])C8=CC=C(O)C=C8CC[C@]7([H])C9=CC=CC=C9)C=C6)CC5)C%10=C2OCO%10
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Immunoprecipitation
Immunoprecipitation (IP) is an experimental method that uses the principle of antibody specific binding to purify and enrich target proteins.
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC ERα Y537S degrader-1 Related Classifications
HY-145071 Related Classifications
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