2. PROTAC MAPK/ERK Pathway GPCR/G Protein
  3. SOS1 PROTACs Ras
  4. PROTAC SOS1 degrader-3

PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

PROTAC SOS1 degrader-3

PROTAC SOS1 degrader-3 화학구조

CAS No. : 3029320-99-5

사이즈 재고
50 mg   견적 받기  
100 mg   견적 받기  
250 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

PROTAC SOS1 degrader-3 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Ras Isoform Specific Products:

View All Isoforms
K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system[1].

IC50 & Target[1]

Cereblon

 

SOS1

 

In Vitro

PROTAC SOS1 degrader-3 (P7; 0.1-10 μM; 6 hours) induces SOS1 degradation in SW620 cells. In addition to SW620, PROTAC SOS1 degrader-3 also induces SOS1 degradation in other colorectal cancer (CRC) cell lines HCT116, C2BB, and SW1417 in a concentration-dependent manner. The half maximal degradation concentration (DC50) for SW620, HCT116, and SW1417 at 24 h is 0.59 μM, 0.75 μM, and 0.19 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC SOS1 degrader-3 Related Antibodies

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 0.1 μM, 1 μM, 10 μM
Incubation Time: 6 hours
Result: Induced SOS1 degradation.
분자량

691.66

화학식

C34H32F3N7O6
CAS No.
SMILES

NC1=CC(C(F)(F)F)=CC([C@H](NC2=C3C=C(OC)C(OCC(NC4=CC=CC(C5=O)=C4CN5C(C(N6)=O)CCC6=O)=O)=CC3=NC(C)=N2)C)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PROTAC SOS1 degrader-3 Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC SOS1 degrader-33029320-99-5SOS1PROTACsRasRas/Rac guanine nucleotide exchange factor 1PROTAC SOS1 degraderubiquitin-proteasome systemKRAScolorectal cancerInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
PROTAC SOS1 degrader-3
Cat. No.:
HY-152145
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.