FGF-4
FGF-4 was first isolated as a transforming oncogene from a gastric carcinoma and as the Kaposi sarcoma oncogene, yet its physiological importance is developmental. Secreted from the apical ectodermal ridge of the limb bud and from the primitive streak, FGF-4 sustains limb outgrowth and posterior patterning and helps maintain pluripotency of embryonic stem cells through FGFR1 and FGFR2 signaling, a property exploited in ES-cell culture media. FGF-4 also acts in tooth and inner-ear development, and autocrine FGF-4 loops have been described in several carcinomas. Recombinant FGF-4 is routinely used to expand mouse and human embryonic stem cells and to study FGFR activation.
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FGF-4 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
