PT2399 (Standard)
PT2399 (Standard) is the analytical standard of PT2399 (HY-108697). This product is intended for research and analytical applications. PT2399 is a selective and orally active HIF-2α antagonist (IC50 < 5 nM) that binds the PAS-B domain and disrupts HIF-2α-ARNT heterodimerization. PT2399 inhibits HIF-2α-driven transcription, destabilizes HIF-2α, and suppresses HIF target genes without inhibiting HIF1α. PT2399 reduces tumor cell proliferation, vessel area, circulating tumor-derived VEGFA/VEGF, and lactate while increasing pyruvate. PT2399 can be used for research on clear cell renal cell carcinoma and chronic myeloid leukemia (CML).
For research use only. We do not sell to patients.
- CAS No.: 1672662-14-4
- Formula: C17H10F5NO4S
- Molecular Weight:419.32
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
-
HY-108697
PT2399HIF-2α Antagonist -
HY-18777
KC7F2HIF/HIF Prolyl-Hydroxylase Inhibitor -
HY-120110
IOX4PHD2 Inhibitor -
HY-12867
PT-2385HIF-2α Inhibitor -
HY-13426
RoxadustatHIF-PH Inhibitor -
HY-101023
MK-8617HIF PHD1-3 Inhibitor -
HY-111387
IDF-11774HIFα-1 Inhibitor -
HY-15468
IOX2HIF/HIF Prolyl-Hydroxylase Inhibitor -
HY-125840
BelzutifanHIF-2α Inhibitor -
HY-15641
FG-2216HIF-PHD2 Inhibitor -
HY-12754
ML228HIF Activator -
HY-15836
BAY 87-2243HIF-1 Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 1672662-14-4
-
Molecular Weight 419.32
-
Formula C17H10F5NO4S
-
SMILES
N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C(F)F)=O)C3=C2CC(F)(F)[C@H]3O)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen W, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016 Nov 3;539(7627):112-117. [Content Brief]
[2]. Cho H, et al. On-Target Efficacy of a HIF2α Antagonist in Preclinical Kidney Cancer Models. Nature. Nature. 2016 Nov 3;539(7627):107-111. [Content Brief]
[3]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PT2399 (Standard) Related Classifications
HY-108697R Related Classifications
Powered by Bioz
Keywords