(R)-PR-924

Cat. No.: HY-123587A: FAQs
Data Sheet Handling Instructions

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(R)-PR-924 is the isomer of PR-924 (HY-123587), and can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC₅₀ of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities.

For research use only. We do not sell to patients.

(R)-PR-924 Chemical Structure

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 476	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 476	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2800	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-PR-924:

PR-924 In-stock

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Description

Molecular Weight

618.72

Formula

C₃₇H₃₈N₄O₅

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H](CC1=CC=CC=C1)C([C@]2(CO2)C)=O)[C@H](NC([C@@H](C)NC(C(CC3=CC=CC=C43)=C4C)=O)=O)CC5=CNC6=CC=CC=C56

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (202.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6162 mL	8.0812 mL	16.1624 mL
5 mM	0.3232 mL	1.6162 mL	3.2325 mL
10 mM	0.1616 mL	0.8081 mL	1.6162 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Singh AV, et al. PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo. Br J Haematol. 2011 Jan;152(2):155-63. [Content Brief]

[2]. Parlati F, et al. Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood. 2009 Oct 15;114(16):3439-47. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6162 mL	8.0812 mL	16.1624 mL	40.4060 mL
	5 mM	0.3232 mL	1.6162 mL	3.2325 mL	8.0812 mL
	10 mM	0.1616 mL	0.8081 mL	1.6162 mL	4.0406 mL
	15 mM	0.1077 mL	0.5387 mL	1.0775 mL	2.6937 mL
	20 mM	0.0808 mL	0.4041 mL	0.8081 mL	2.0203 mL
	25 mM	0.0646 mL	0.3232 mL	0.6465 mL	1.6162 mL
	30 mM	0.0539 mL	0.2694 mL	0.5387 mL	1.3469 mL
	40 mM	0.0404 mL	0.2020 mL	0.4041 mL	1.0102 mL
	50 mM	0.0323 mL	0.1616 mL	0.3232 mL	0.8081 mL
	60 mM	0.0269 mL	0.1347 mL	0.2694 mL	0.6734 mL
	80 mM	0.0202 mL	0.1010 mL	0.2020 mL	0.5051 mL
	100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.4041 mL

(R)-PR-924 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-PR-924OthersLMP-7tripeptideepoxyketonecovalentlyN-terminalthreonineshIL-6Rβ5imitochondriaantitumorapoptosisInhibitorinhibitorinhibit

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(R)-PR-924

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Complete Stock Solution Preparation Table

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