1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. (R,R)-THC

(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6.

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(R,R)-THC Chemical Structure

(R,R)-THC Chemical Structure

CAS No. : 221368-54-3

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Description

(R,R)-THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R,R)-THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].

IC50 & Target[1]

ERα

9.0 nM (Ki)

ERβ

3.6 nM (Ki)

Molecular Weight

320.42

Formula

C22H24O2

CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

OC(C=C1C[C@H]2CC)=CC=C1C3=C2C4=C(C=C(O)C=C4)C[C@H]3CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(R,R)-THC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(R,R)-THC
Cat. No.:
HY-103451
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