2. Others
  3. Isotope-Labeled Compounds
  4. (S)-Malic acid-13C4

(S)-Malic acid-13C4  (Synonyms: (S)-Hydroxybutanedioic acid-13C4; (S)-E 296-13C4; L-Malic acid-13C4)

Cat. No.: HY-Y1069S3 Purity: 98.2%
COA
SDS
Handling Instructions Technical Support

(S)-Malic acid-13C4 is the 13C labeled S-Malic acid (HY-Y1069).

For research use only. We do not sell to patients.

(S)-Malic acid-<sup>13</sup>C<sub>4</sub>

(S)-Malic acid-13C4 Chemical Structure

CAS No. : 150992-96-4

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Other Forms of (S)-Malic acid-13C4:

(S)-Malic acid-13C4 Related Antibodies

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  • Purity & Documentation

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Description

(S)-Malic acid-13C4 is the 13C labeled S-Malic acid (HY-Y1069)[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L. casei. Furthermore, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose, whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-Malic acid-13C4 Related Antibodies
Molecular Weight

138.06

Formula

13C4H6O5
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O[13C]([13CH2][13C@H](O)[13C](O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (724.32 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2432 mL 36.2161 mL 72.4323 mL
5 mM 1.4486 mL 7.2432 mL 14.4865 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.2%

SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.2432 mL 36.2161 mL 72.4323 mL 181.0807 mL
5 mM 1.4486 mL 7.2432 mL 14.4865 mL 36.2161 mL
10 mM 0.7243 mL 3.6216 mL 7.2432 mL 18.1081 mL
15 mM 0.4829 mL 2.4144 mL 4.8288 mL 12.0720 mL
20 mM 0.3622 mL 1.8108 mL 3.6216 mL 9.0540 mL
25 mM 0.2897 mL 1.4486 mL 2.8973 mL 7.2432 mL
30 mM 0.2414 mL 1.2072 mL 2.4144 mL 6.0360 mL
40 mM 0.1811 mL 0.9054 mL 1.8108 mL 4.5270 mL
50 mM 0.1449 mL 0.7243 mL 1.4486 mL 3.6216 mL
60 mM 0.1207 mL 0.6036 mL 1.2072 mL 3.0180 mL
80 mM 0.0905 mL 0.4527 mL 0.9054 mL 2.2635 mL
100 mM 0.0724 mL 0.3622 mL 0.7243 mL 1.8108 mL
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(S)-Malic acid-13C4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Malic acid-13C4150992-96-4(S)-Hydroxybutanedioic acid-13C4(S)-E 296-13C4 L-Malic acid-13C4Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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