2. GPCR/G Protein
  3. LPL Receptor
  4. S1PR1 modulator 1

S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4.

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S1PR1 modulator 1 Chemical Structure

S1PR1 modulator 1 Chemical Structure

CAS No. : 2328109-05-1

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Based on 1 publication(s) in Google Scholar

S1PR1 modulator 1 Related Antibodies

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Description

S1PR1 modulator 1 is a selective S1PR1 inhibitor, with a pIC50 of 7.6, with >40- and >80-fold selectivity, over the other S1PR isoforms S1PR2/3/4[1].

IC50 & Target

pIC50: 7.6 (S1PR1), 6 (S1PR3)[1]
In Vitro

S1PR1 modulator 1 (Compound 10a; (Z,Z)-10a) is selective at S1PR1 over S1PR3 (pIC50, 6), S1PR2 and S1PR4 (pIC50s, <5)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S1PR1 modulator 1 Related Antibodies
Molecular Weight

408.51

Formula

C23H24N2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC=C1N2C(/C(S/C2=N\CCC)=C/C3=CC=C(OC(C)=O)C(C)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (153.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4479 mL 12.2396 mL 24.4792 mL
5 mM 0.4896 mL 2.4479 mL 4.8958 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4479 mL 12.2396 mL 24.4792 mL 61.1980 mL
5 mM 0.4896 mL 2.4479 mL 4.8958 mL 12.2396 mL
10 mM 0.2448 mL 1.2240 mL 2.4479 mL 6.1198 mL
15 mM 0.1632 mL 0.8160 mL 1.6319 mL 4.0799 mL
20 mM 0.1224 mL 0.6120 mL 1.2240 mL 3.0599 mL
25 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4479 mL
30 mM 0.0816 mL 0.4080 mL 0.8160 mL 2.0399 mL
40 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5300 mL
50 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
60 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0200 mL
80 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7650 mL
100 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
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S1PR1 modulator 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S1PR1 modulator 12328109-05-1LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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