1. Anti-infection
  2. Bacterial
  3. Sapienic acid

Sapienic acid 

Cat. No.: HY-130187
Handling Instructions

Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively.

For research use only. We do not sell to patients.

Sapienic acid Chemical Structure

Sapienic acid Chemical Structure

CAS No. : 17004-51-2

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Description

Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively[1].

IC50 & Target

MBC: 31.3 μg/mL (Streptococcus sanguinis), 375.0 μg/mL (Streptococcus mitis) and 93.8 μg/mL (Fusobacterium nucleatum)[1]

In Vitro

Sapienic acid (minimum bactericidal concentrations (MBCs) range, 31.3 to 375.0 μg/mL) is active against Streptococcus sanguinis, Streptococcus mitis, and Fusobacterium nucleatum but not active against Escherichia coli, Staphylococcus aureus, S. marcescens, P. aeruginosa, Corynebacterium bovis, Corynebacterium striatum, and Corynebacterium jeikeium (MBC > 500 μg/mL). Kinetic assays show that killing of S. sanguinis and S. mitis with sapienic acid is gradual and occurred within 24 h[1].

Molecular Weight

254.41

Formula

C₁₆H₃₀O₂

CAS No.

17004-51-2

SMILES

CCCCCCCCC/C=C\CCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Sapienic acidBacterialAntibacteriallipidsMBCGram-positiveGram-negativeskinoralcavityInhibitorinhibitorinhibit

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Sapienic acid
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