TWH106
TWH106 is an inhibitor for Cyclophilin (Cyp) that exhibits good affinity to CypA and CypB with KD of 53 nM and 139 nM. TWH106 inhibits the replication of HIV and HCV, exhibiting antiviral activity.
For research use only. We do not sell to patients.
- Formula: C32H34N6O7
- Molecular Weight:614.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Cyclophilin Isoforms
More
Biological Activity
Description
IC50 & Target
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Cyclophilin A 53 nM (Kd) |
Cyclophilin B 139 nM (Kd) |
Chemical Information
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Molecular Weight 614.65
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Formula C32H34N6O7
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SMILES
O=C([C@@H]1CCCN(N1)C([C@@H](NC([C@@H](NC(C/C=C/2)=O)CC3=CC=C(C=C3)[N+]([O-])=O)=O)C)=O)O[C@H](C)C4=CC=C5C=CC2=CC5=N4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TWH106 Related Classifications
HY-173013 Related Classifications
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