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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
265 Results for "
Folate
" in MedChemExpress (MCE) Product Catalog:
Products (265)
265 Results for "Folate" in MCE Product Catalog:
Cat. No.: HY-12784AR
CAS No.: 152-53-4
Synonyms: Chlorguanide triazine hydrochloride (Standard)
Cycloguanil hydrochloride (Standard) is the analytical standard of Cycloguanil hydrochloride (HY-12784A). This product is intended for research and analytical applications. Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .
Cat. No.: HY-B0688S2
CAS No.: 1632119-29-9
Synonyms: 4,4′-Diaminodiphenyl sulfone-13C12; DDS-13C12
Cat. No.: HY-B0688S3
CAS No.: 287476-19-1
Synonyms: 4,4′-Diaminodiphenyl sulfone-15N2; DDS-15N2
Cat. No.: HY-P99612
CAS No.: 2407465-18-1
Synonyms: MORAb-202
Target:
Research Areas:
Farletuzumab ecteribulin (MORAb-202) is an antibody-drug conjugate (ADC), consisting of the humanized anti-human folate receptor alpha (FRA) antibody Farletuzumab (HY-P99153) conjugated via reduced interchain disulfide bonds to Mal-PEG2-Val-Cit-PAB-eribulin. Farletuzumab ecteribulin has a agent-to-antibody ratio of 4.0. Farletuzumab ecteribulin is highly cytotoxic to FRA-positive cells in vitro. Farletuzumab ecteribulin has potent antitumor activity.
Cat. No.: HY-P706205
Purity: ≥ 95%, as determined by reducing SDS-PAGE. ≥ 90%, as determined by SEC-MALS.
Synonyms: GCP2; PSMA; PSMAFGCP; FGCP; Folate hydrolase 1; FOLHNAALADase I; GCPII; GCPIImGCP; NAALAD1; NAALADase I; NAALAdase; FOLH1; GIG27; PSM; FOLH; mGCP
Species:
Rat
Source:
HEK293
Cat. No.: HY-119143
CAS No.: 32093-09-7
Research Areas:
CB 3703 is an inhibitor of thymidylate synthase (TS) and dihydrofolate reductase (DHFR). CB 3703 has an IC50 of 0.25 μM against rat TS, a Ki of 0.47 μM against mouse TS, an IC50 of 6.8 nM against rat DHFR, and a Ki of 0.6 pM against mouse DHFR. CB 3703 is transported via the reduced folate pathway, has a short plasma half-life, and can prolong the survival of tumor-bearing mice. CB 3703 can be used in the research of L1210 ascites tumors .
Cat. No.: HY-12784AS
CAS No.: 1189427-23-3
Synonyms: Chlorguanide triazine-d4 hydrochloride
Cat. No.: HY-12784AS1
CAS No.: 2712364-69-5
Synonyms: Chlorguanide triazine-d6 hydrochloride
Cat. No.: HY-P10762
CAS No.: 2082631-84-1
Synonyms: CBP-1008; LDC 10B
Research Areas:
Cat. No.: HY-12784S1
CAS No.: 2070015-19-7
Synonyms: Chlorguanide triazine-d6 nitrate
Cat. No.: HY-158082B
Synonyms: Tetramethyl rhodamine isothiocyanate glucan, MW 40000
Target:
Research Areas:
TRITC-dextran (Tetramethyl rhodamine isothiocyanate glucan), MW 40000 is a TRITC (HY-D0791)-labeled neutral 40 kDa fluorescent polysaccharide probe. TRITC-dextran, MW 40000 forms a membrane layer on the surface of protocells composed of protamine/folate condensates, and is used to assess membrane fluidity via fluorescence recovery after photobleaching. TRITC-dextran, MW 40000 can also be used to evaluate the anti-bacterial invasion ability and colloidal stability of coated condensates, as well as analyze the permeability of vascular and lymphatic endothelial cell layers .
Cat. No.: HY-P992004
Synonyms: RA15-7, HuRA15-7Acc
Target:
Research Areas:
Cat. No.: HY-W053583R
CAS No.: 60239-18-1
Synonyms: DOTA (Standard)
Research Areas:
Tetraxetan (Standard) is the analytical standard of Tetraxetan (HY-W053583). This product is intended for research and analytical applications. Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) .
Cat. No.: HY-P76953
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GGH; GH; Gamma-Glutamyl Hydrolase; Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase); Gamma-Glu-X Carboxypeptidase; Folylpolygammaglutamyl Hydrolase; Conjugase; Folate Gamma-Glutamyl Hydrolase; GATD10
Species:
Human
Source:
HEK293
Target:
Cat. No.: HY-P70548A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLH1; Folylpoly-Gamma-Glutamate Carboxypeptidase; Prev. FOLH; Membrane Glutamate Carboxypeptidase; NAALAD1; Glutamate Carboxylase II; GCPII; NAALADase I; PSMA; NAALAdase; PSM; FGCP; Glutamate Carboxypeptidase II; MGCP; Glutamate Carboxypeptidase 2; Folate Hydrolase (Prostate-Specific Membrane Antigen) 1; GCP2; N-Acetylated Alpha-Linked Acidic Dipeptidase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Prostate-Specific Membrane Antigen; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folate Hydrolase 1; Cell Growth-Inhibiting Gene 27 Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-P700006
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLH1; Folylpoly-Gamma-Glutamate Carboxypeptidase; Prev. FOLH; Membrane Glutamate Carboxypeptidase; NAALAD1; Glutamate Carboxylase II; GCPII; NAALADase I; PSMA; NAALAdase; PSM; FGCP; Glutamate Carboxypeptidase II; MGCP; Glutamate Carboxypeptidase 2; Folate Hydrolase (Prostate-Specific Membrane Antigen) 1; GCP2; N-Acetylated Alpha-Linked Acidic Dipeptidase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Prostate-Specific Membrane Antigen; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folate Hydrolase 1; Cell Growth-Inhibiting Gene 27 Protein
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P705201
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLH1; Folylpoly-Gamma-Glutamate Carboxypeptidase; Prev. FOLH; Membrane Glutamate Carboxypeptidase; NAALAD1; Glutamate Carboxylase II; GCPII; NAALADase I; PSMA; NAALAdase; PSM; FGCP; Glutamate Carboxypeptidase II; MGCP; Glutamate Carboxypeptidase 2; Folate Hydrolase (Prostate-Specific Membrane Antigen) 1; GCP2; N-Acetylated Alpha-Linked Acidic Dipeptidase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Prostate-Specific Membrane Antigen; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folate Hydrolase 1; Cell Growth-Inhibiting Gene 27 Protein
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-181100
Research Areas:
DHFR-IN-26 is an Escherichia coli dihydrofolate reductase (ecDHFR) inhibitor with an IC50 of 0.75 nM. DHFR-IN-26 exerts broad-spectrum antibacterial activity. DHFR-IN-26 disrupts folate metabolism, nucleotide synthesis, and bacterial amino acid metabolic pathways. DHFR-IN-26 disrupts bacterial inner membranes, inhibited biofilm formation, and attenuated phage-related processes. DHFR-IN-26 shows lower toxicity to non-cancerous cells. DHFR-IN-26 can be used for the research of bacterial infections (including infections caused by methicillin-resistant Staphylococcus aureus, multidrug-resistant Escherichia coli, multidrug-resistant Pseudomonas aeruginosa, and lysogenic bacteria) .
Cat. No.: HY-P992515
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
