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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
293 Results for "
Mixed
" in MedChemExpress (MCE) Product Catalog:
Products (293)
293 Results for "Mixed" in MCE Product Catalog:
Cat. No.: HY-W747104
CAS No.: 52957-16-1
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Cat. No.: HY-100908R
CAS No.: 1016-47-3
Synonyms: N10-Acetyltryptamine (Standard); Nb-Acetyltryptamine (Standard); Nω-Acetyltryptamine (Standard)
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N-Acetyltryptamine (Standard) (N10-Acetyltryptamine (Standard); Nb-Acetyltryptamine (Standard); Nω-Acetyltryptamine (Standard)) is the analytical standard of N-Acetyltryptamine (HY-100908). This product is intended for research and analytical applications. N-Acetyltryptamine (N10-Acetyltryptamine) is a mixed agonist-antagonist of the melatonin receptor. N-Acetyltryptamine inhibits acetylserotonin methyltransferase, blocks the conversion of N-acetylserotonin to melatonin, and inhibits neuronal firing activity in suprachiasmatic nucleus neurons. N-Acetyltryptamine is a physiological constituent of mammalian blood. N-Acetyltryptamine is a metabolite of tryptamine in Bacillus cereus .
Cat. No.: HY-117649
CAS No.: 120382-04-9
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RU-39411 is a steroidal anti-estrogen with mixed estrogenic/antiestrogen activity. RU-39411 has shown inhibitory effects on cell growth in the MCF-7 breast cancer model, with the effect being correlated with its binding affinity to the estrogen receptor. RU-39411 was able to downregulate the estrogen binding capacity of cells, but did not reduce estrogen receptor mRNA levels, indicating that the grafting of its side chain prevents the antagonistic effects usually associated with steroidal estrogens. The administration of RU-39411 can promote the synthesis of progesterone receptors, further supporting its activity as an estrogen .
Cat. No.: HY-178464
CAS No.: 3065634-19-4
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RIPK1-IN-34 is a selective, brain-penetrant RIPK1 inhibitor (IC50 = 126.70 nM) with almost no inhibitory effect on RIPK3 (IC50 ＞ 10, 000 nM). RIPK1-IN-34 offers substantial neuroprotection by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) within the necroptosis pathway. RIPK1-IN-34 shows the neuroprotective effect in a rat middle cerebral artery occlusion (MCAO) model. RIPK1-IN-34 can be used for the study of anti-acute ischemic stroke (AIS) .
Cat. No.: HY-181029
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Tyrosinase-IN-49 (Compound 12) is a potent and mixed-type chalcone-based tyrosinase inhibitor with an IC50 of 0.19 μM. Tyrosinase-IN-49 has potent antioxidant potential with significant DPPH and ABTS radical scavenging capacity. Tyrosinase-IN-49 can chelate the binuclear copper ions in the active center of tyrosinase and reduce Cu 2+ to Cu +, thereby reducing the catalytic activity of the enzyme. Tyrosinase-IN-49 has low cytotoxicity for HEK293 cells and zebrafish embryo. Tyrosinase-IN-49 shows antibrowning effects to improve food quality and can be used for research of food preservation .
Cat. No.: HY-183957
CAS No.: 96883-54-4
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(Z,E)-7,11-Hexadecadienal is a geometric isomer of Z7,Z11-16:Ald, the core component of the citrus leafminer sex pheromone. (Z,E)-7,11-Hexadecadienal acts as a sex pheromone tropism inhibitor; when mixed with the sex pheromone Z7,Z11-16:Ald, it blocks the tropism of male citrus leafminers towards the sex pheromone component. (Z,E)-7,11-Hexadecadienal can be used in insect resistance-related research .
Cat. No.: HY-187598
CAS No.: 144674-89-5
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U 89674 is a nonnucleoside HIV-1 reverse transcriptase inhibitor with no cytotoxic effect on cells at concentrations of 10 μM or lower over 7 days. U 89674 modulates reverse transcriptase activity, interfering with HIV-1 replication. U 89674 inhibits replication of HIV-1 laboratory strains and primary HIV-1 isolates in immune cells. U 89674 delays virus-induced cell killing in mixed cultures of uninfected and HIV-1-infected cells. U 89674 can be used for the research of HIV-1 infection .
Cat. No.: HY-N12885
CAS No.: 73264-89-8
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Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia .
Cat. No.: HY-W780694
CAS No.: 112654-98-5
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PD 124816 is an orally active fluoroquinolone antibiotic. PD 124816 exerts broad-spectrum antibacterial effects by inhibiting DNA gyrase (topoisomerase IV), and it has no cross-resistance with commonly used antibiotics. PD 124816 is effective against both Gram-positive and Gram-negative bacteria (MIC₉₀ ≤ 0.06 μg/mL), and the MIC₉₀ for anaerobic bacteria (Peptostreptococcus fragi) is 1 μg/mL. PD 124816 exhibits complete bactericidal activity in a mouse model of Mycobacterium leprae infection. PD 124816 can be used for studying mixed infections and infections caused by drug-resistant bacteria .
Cat. No.: HY-W795967
CAS No.: 108605-69-2
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2-Thiouridine is an orally active modified nucleobase. 2-Thiouridine stabilizes U:A base pairs and destabilizes U:G wobble base pairs. 2-Thiouridine significantly improves the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. 2-Thiouridine exhibits antiviral activity against multiple positive-sense single-stranded RNA viruses (DENV2, ZIKV, YFV, JEV, WNV, CHIKV, human coronaviruses ( [HCoV]-229E, HCoV-OC43, SARS-CoV), and MERS-CoV) .
Cat. No.: HY-121382R
CAS No.: 639-14-5
Cat. No.: HY-128443R
CAS No.: 122-19-0
Synonyms: BDMSAC (Standard)
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Benzyldimethylstearylammonium chloride (Standard) (BDMSAC (Standard)) is the analytical standard of Benzyldimethylstearylammonium chloride (HY-128443). This product is intended for research and analytical applications. Benzyldimethylstearylammonium chloride is a quaternary ammonium cationic surfactant and a mixed-type corrosion inhibitor. Benzyldimethylstearylammonium chloride adsorbs onto the surface of cold-rolled steel through a combined effect of physisorption and chemisorption, forming a hydrophobic protective barrier that blocks active sites and restricts the diffusion of corrosive media, while simultaneously inhibiting the anodic iron dissolution reaction and the cathodic hydrogen evolution reaction, and reducing the corrosion rate in acidic media. Benzyldimethylstearylammonium chloride is used in research related to various fields such as fungicides, wastewater treatment, and detergents .
Cat. No.: HY-129591
CAS No.: 77392-58-6
Synonyms: PNU-97333
Paraherquamide A (PNU-97333) is an anthelmintic and nicotinic acetylcholine receptor (nAChR) antagonist, with pIC50 values ranging from 6.87 to 7.58 for L-type nAChR and from 4.84 to 5.54 for N-type nAChR. Paraherquamide A acts as a competitive antagonist against multiple nematode nAChR subtypes, as well as a mixed competitive-noncompetitive antagonist against nematode N-type nAChR. Paraherquamide A induces flaccid paralysis in parasitic nematodes without altering ATP levels, inhibits nematode motility, and antagonizes cholinergic agonist-induced muscle contraction in nematodes. Paraherquamide A can be used in studies related to nematode parasitic infections .
Cat. No.: HY-14532S
CAS No.: 1917374-64-1
Synonyms: CMX001-d6; HDP-CDV-d6
Cat. No.: HY-169093
CAS No.: 2768610-97-3
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MS41 is a ENL PROTAC degrader with a DC50 of 3.50 nM. MS41 recruits the VHL E3 ubiquitin ligase, triggers ENL degradation via the ubiquitin-proteasome system, and simultaneously induces AF9 degradation. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation complexes, suppresses oncogene expression, and activates differentiation gene expression. MS41 inhibits leukemia cell growth and induces cell cycle arrest and apoptosis. MS41 inhibits leukemia progression in xenograft mouse models. MS41 can be used for research on mixed lineage leukemia-rearranged leukemia and nephroblastoma .
Cat. No.: HY-178374
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BACE-1/Mpro-IN-1 is a high brain-penetrant BACE-1 (IC50 = 0.26 μM) and SARS-CoV-2 Mpro (IC50 = 0.91 μM) dual inhibitor. BACE-1/Mpro-IN-1 binds to the aspartyl protease and cysteine protease as a mixed-type inhibitor. BACE-1/Mpro-IN-1 exhibits the most favorable docking score and a strong interaction profile. BACE-1/Mpro-IN-1 can be used for the study of COVID-19 exacerbated Neuroinflammation and Alzheimer’s disease .
Cat. No.: HY-189143
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Xanthine oxidase-IN-24 is an orally active mixed-type inhibitor of xanthine oxidase, with an IC50 of 0.051 μM and a Ki of 0.162 μM. Xanthine oxidase-IN-24 interacts with both free xanthine oxidase and the xanthine-xanthine oxidase complex, and reduces uric acid production in vivo. In a rat model of hyperuricemia induced by Potassium oxonate (HY-17511), Xanthine oxidase-IN-24 dose-dependently lowers serum uric acid levels, improves renal function-related biochemical parameters such as creatinine and urea nitrogen, and alleviates histopathological damage to liver and kidney tissues. Xanthine oxidase-IN-24 can be used in the research of hyperuricemia .
Cat. No.: HY-N17215
CAS No.: 99523-99-6
Synonyms: 3,4,6-Trigalloylglucose
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
