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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3437 Results for "
II
" in MedChemExpress (MCE) Product Catalog:
Products (3437)
3437 Results for "II" in MCE Product Catalog:
Cat. No.: HY-P70478
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGR2A; Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32); Prev. FCGR2A1; Fc Fragment Of IgG Receptor IIa; Prev. FCG2; IgG Fc Receptor II-A; Prev. FCGR2; FcRII-A; Fc-Gamma-RIIa; Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32); IGFR2; Fc Gamm
Species:
Human
Source:
HEK293
Cat. No.: HY-P70950
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IGF2BP2; VICKZ2; Insulin Like Growth Factor 2 MRNA Binding Protein 2; IMP2; IMP-2; P62; Insulin-Like Growth Factor 2 MRNA-Binding Protein 2; Truncated Insulin-Like 2 Growth Factor 2-Binding Protein 2; IGF-II MRNA-Binding Protein 2; Insulin-Like Growth Fac
Species:
Human
Source:
E. coli
Cat. No.: HY-P74850
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGF2BP2; VICKZ2; Insulin Like Growth Factor 2 MRNA Binding Protein 2; IMP2; IMP-2; P62; Insulin-Like Growth Factor 2 MRNA-Binding Protein 2; Truncated Insulin-Like 2 Growth Factor 2-Binding Protein 2; IGF-II MRNA-Binding Protein 2; Insulin-Like Growth Fac
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P76429
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL20RB; Interleukin-20 Receptor Subunit Beta; Prev. FNDC6; IL-20R-Beta; IL-20R2; MGC34923; DIRS1; IL-20RB; Fibronectin Type III Domain Containing 6; Interleukin 20 Receptor Beta; Interleukin 20 Receptor Beta Subunit; Interleukin-20 Receptor II; Interleukin 20 Receptor Subunit Beta; IL-20 Receptor Subunit Beta
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P703926
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CNDP2; Glutamate Carboxypeptidase-Like Protein 1; Prev. PEPA; Carnosine Dipeptidase II; CPGL; CNDP Dipeptidase 2; CN2; Carnosinase-2; Cytosolic Non-Specific Dipeptidase; FLJ10830; Threonyl Dipeptidase; HEL-S-13; Peptidase A; Epididymis Secretory Protein Li 13; HsT2298; Alternative Protein CNDP2; CNDP Dipeptidase 2 (Metallopeptidase M20 Family); Carnosine Dipeptidase 2; Cytosolic Nonspecific Dipeptidase
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P704590
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGR2A; Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32); Prev. FCGR2A1; Fc Fragment Of IgG Receptor IIa; Prev. FCG2; IgG Fc Receptor II-A; Prev. FCGR2; FcRII-A; Fc-Gamma-RIIa; Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32); IGFR2; Fc Gamm
Species:
Human
Source:
HEK293
Cat. No.: HY-P86919
Synonyms: AN 2 antibody; AN antibody; AN2 antibody; Aniridia type II protein antibody; D11S812E antibody; FVH1 antibody; KIAA0552 antibody; Leucine zipper putative tumor suppressor 3 antibody; LZTS3 antibody; MGC17209 antibody; AN 2 antibody; AN antibody; AN2 antibody; Aniridia type II protein antibody; D11S812E antibody; FVH1 antibody; KIAA0552 antibody; Leucine zipper putative tumor suppressor 3 antibody; LZTS3 antibody; MGC17209 antibody; MGDA antibody; Oculorhombin antibody; Paired box 6 antibody; Paired box gene 6 (aniridia keratitis) antibody; Paired Box Gene 6 antibody; Paired box homeotic gene 6 antibody; Paired box protein Pax-6 antibody; Paired box protein Pax6 antibody; PAX 6 antibody; PAX6 antibody; PAX6_HUMAN antibody; ProSAP-interacting protein 1 antibody; PROSAPIP1 antibody; Sey antibody; WAGR antibody;
Cat. No.: HY-P85872
Synonyms: Mediator of RNA polymerase II transcription subunit 1; Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Peroxisome proliferator-activated receptor-binding protein; PBP; PPAR-binding protein; Thyroid hormone receptor-associated protein complex 220 kDa component; Trap220; Thyroid receptor-interacting protein 2; TR-interacting protein 2; TRIP-2; Vitamin D receptor-interacting protein complex component DRIP205;
Cat. No.: HY-P812030
Synonyms: MED27; Mediator Complex Subunit 27; CRSP34; TRAP37; CRSP8; MED3; Cofactor Required For Sp1 Transcriptional Activation, Subunit 8, 34kDa; Mediator Of RNA Polymerase II Transcription Subunit 27; Transcriptional Coactivator CRSP34; P37 TRAP/SMCC/PC2 Subunit; CRSP Complex Subunit 8; Cofactor Required For Sp1 Transcriptional Activation Subunit 8; Epididymis Secretory Sperm Binding Protein; NEDSCAC; CRAP34
Cat. No.: HY-P77001
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL22RA1; Interleukin 22 Receptor, Alpha 1; Prev. IL22R; IL-22R-Alpha-1; CRF2-9; IL-22RA1; Interleukin-22 Receptor Subunit Alpha-1; ZcytoR11; Cytokine Receptor Class-II Member 9; Interleukin 22 Receptor; Cytokine Receptor Family 2 Member 9; IL22R1; Interle
Species:
Rat
Source:
HEK293
Cat. No.: HY-P77002
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: IL22RA1; Interleukin 22 Receptor, Alpha 1; Prev. IL22R; IL-22R-Alpha-1; CRF2-9; IL-22RA1; Interleukin-22 Receptor Subunit Alpha-1; ZcytoR11; Cytokine Receptor Class-II Member 9; Interleukin 22 Receptor; Cytokine Receptor Family 2 Member 9; IL22R1; Interle
Species:
Rat
Source:
HEK293
Cat. No.: HY-P77423
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: IL22RA1; Interleukin 22 Receptor, Alpha 1; Prev. IL22R; IL-22R-Alpha-1; CRF2-9; IL-22RA1; Interleukin-22 Receptor Subunit Alpha-1; ZcytoR11; Cytokine Receptor Class-II Member 9; Interleukin 22 Receptor; Cytokine Receptor Family 2 Member 9; IL22R1; Interle
Species:
Canine
Source:
HEK293
Cat. No.: HY-P77424
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL22RA1; Interleukin 22 Receptor, Alpha 1; Prev. IL22R; IL-22R-Alpha-1; CRF2-9; IL-22RA1; Interleukin-22 Receptor Subunit Alpha-1; ZcytoR11; Cytokine Receptor Class-II Member 9; Interleukin 22 Receptor; Cytokine Receptor Family 2 Member 9; IL22R1; Interle
Species:
Canine
Source:
HEK293
Cat. No.: HY-P700744
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL22RA1; Interleukin 22 Receptor, Alpha 1; Prev. IL22R; IL-22R-Alpha-1; CRF2-9; IL-22RA1; Interleukin-22 Receptor Subunit Alpha-1; ZcytoR11; Cytokine Receptor Class-II Member 9; Interleukin 22 Receptor; Cytokine Receptor Family 2 Member 9; IL22R1; Interle
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P703975
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IL22RA1; Interleukin 22 Receptor, Alpha 1; Prev. IL22R; IL-22R-Alpha-1; CRF2-9; IL-22RA1; Interleukin-22 Receptor Subunit Alpha-1; ZcytoR11; Cytokine Receptor Class-II Member 9; Interleukin 22 Receptor; Cytokine Receptor Family 2 Member 9; IL22R1; Interle
Species:
Human
Source:
HEK293
Cat. No.: HY-P812030A
Synonyms: MED27; Mediator Complex Subunit 27; CRSP34; TRAP37; CRSP8; MED3; Cofactor Required For Sp1 Transcriptional Activation, Subunit 8, 34kDa; Mediator Of RNA Polymerase II Transcription Subunit 27; Transcriptional Coactivator CRSP34; P37 TRAP/SMCC/PC2 Subunit; CRSP Complex Subunit 8; Cofactor Required For Sp1 Transcriptional Activation Subunit 8; Epididymis Secretory Sperm Binding Protein; NEDSCAC; CRAP34
Cat. No.: HY-P86815
Synonyms: ATP/GTP binding protein antibody; Cleavage and polyadenylation factor I subunit 1 antibody; CLP 1 antibody; clp1 antibody; CLP1 cleavage and polyadenylation factor I subunit homolog antibody; CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) antibody; CLP1, yeast, homolog of antibody; CLP1_HUMAN antibody; hClp1 antibody; Homolog of yeast CFIA subunit Clp1p antibody; ATP/GTP binding protein antibody; Cleavage and polyadenylation factor I subunit 1 antibody; CLP 1 antibody; clp1 antibody; CLP1 cleavage and polyadenylation factor I subunit homolog antibody; CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) antibody; CLP1, yeast, homolog of antibody; CLP1_HUMAN antibody; hClp1 antibody; Homolog of yeast CFIA subunit Clp1p antibody; Polyadenylation factor Clp1 antibody; Polynucleotide kinase Clp1 antibody; Polyribonucleotide 5' hydroxyl kinase Clp1 antibody; Polyribonucleotide 5''-hydroxyl-kinase Clp1 antibody; Pre mRNA cleavage complex II protein Clp1 antibody; Pre-mRNA cleavage complex II protein Clp1 antibody;
Cat. No.: HY-173119
Research Areas:
SKLB-D18 is an orally active ERK1/2/ERK5 inhibitor, with an IC50 of 38.69 nM and a Kd of 126.9 nM against human ERK1, an IC50 of 40.12 nM and a Kd of 209.8 nM against ERK2, and an IC50 of 59.72 nM and a Kd of 468.2 nM against ERK5. SKLB-D18 inhibits cancer cell proliferation, induces G0/G1 cell cycle arrest and apoptosis. SKLB-D18 reduces the levels of p-ERK5, p-RSKp90, p-c-Myc and c-Myc, and upregulates the level of p-ERK1/2, thereby inhibiting the ERK1/2/5 pathway in cells. SKLB-D18 increases LC3B-II accumulation, and decreases the levels of p62, p-mTOR and p-p70S6K. SKLB-D18 elevates the levels of ROS, lipid peroxidation and free ferrous ions, reduces the levels of NCOA4 and GPX4, and induces ferritin autophagy-dependent ferroptosis in cancer cells. SKLB-D18 exhibits antitumor activity in a triple-negative breast cancer xenograft mouse model. SKLB-D18 can be used in research related to triple-negative breast cancer .
Cat. No.: HY-184501
CAS No.: 486440-74-8
UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2. UE01 activates hULK1 with an EC50 of 695.30 nM and a KD of 114.3 nM for ULK1; it inhibits hERK1 with an IC50 of 179.90 nM and a KD of 114 nM for ERK1; it shows weak binding to ERK2 with a KD of 2.8 mM. UE01 induces the conformational transition of ULK1 from an inactive to an active state, enhances the phosphorylation of ULK1 Ser317 and mAtg13 Ser355, and reduces the phosphorylation of ULK1 Ser757. UE01 competitively occupies the ATP-binding pocket of ERK1, inhibits ERK1 kinase activity, and reduces the activity of the ERK1/2 signaling pathway. UE01 induces complete autophagy flux and apoptosis, upregulates Atg5, Atg7, LC3-II/LC3-I, Bax, cytochrome C (Cyt c), Cleaved-Caspase 3, Cleaved-PARP1 and E-cadherin, downregulates p62, Bcl-2, MMP-2 and MMP-9, reduces the phosphorylation of Exo70 Ser250, and promotes the proteasome-dependent degradation of Cav-1, thereby inhibiting EMT-related phenotypes and extracellular matrix degradation. UE01 can be used in studies related to triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
