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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
PMN
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "PMN" in MCE Product Catalog:
Cat. No.: HY-N2247A
CAS No.: 88547-66-4
Cat. No.: HY-116444A
CAS No.: 128914-46-5
Target:
Research Areas:
16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease .
Cat. No.: HY-P10738A
Target:
Research Areas:
Cat. No.: HY-106899A
CAS No.: 143445-03-8
Synonyms: (rel)-L-680573
Research Areas:
(rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis .
Cat. No.: HY-117811
CAS No.: 143490-81-7
Synonyms: L-680574
Research Areas:
(R,R)-MK 287 (L-680574) is a tetrahydrofuran derivative that potently inhibits the binding of [3H]C18-PAF to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values of 6.1, 3.2, and 5.49 nM, respectively. (R,R)-MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50=56 nM) and elastase release from PMNs (ED50=4.4 nM). (R,R)-MK 287 inhibits PAF-induced lethality in mice (ED50=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED50=0.18 mg/kg) .
Cat. No.: HY-180351
CAS No.: 2099034-38-3
CU-6PMN is a fluorescent RXR agonist. CU-6PMN has a maximum absorption wavelength of 396 nm and an emission wavelength of 453 nm in 0.1 N NaOH aqueous solution. CU-6PMN has an EC50 value of 22 nM and a Ki value of 230 nM for human RXRα. CU-6PMN can be used in research related to the screening of RXR ligands .
Cat. No.: HY-174313
Research Areas:
Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research .
Cat. No.: HY-125527AS
Synonyms: 17(R)-RvD1-d5; AT-RvD1-d5
Cat. No.: HY-120314A
Target:
Research Areas:
GEA 3162 hydrochloride is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 hydrochloride significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 hydrochloride induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 hydrochloride has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 hydrochloride can be used for research on inflammatory conditions such as gastric ulcers .
Cat. No.: HY-P72179
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ELANE; Polymorphonuclear Leukocyte Elastase; Prev. ELA2; Elastase 2, Neutrophil; HLE; Leukocyte Elastase; Neutrophil Elastase; Elastase-2; PMN Elastase; Granulocyte-Derived Elastase; Medullasin; Polymorphonuclear Elastase; PMN-E; Human Leukocyte Elastase
Species:
Human
Source:
E. coli
Cat. No.: HY-P81215
Synonyms: Bone Marrow Serine Protease; ELA 2; ELA2; ELANE; Elastase 2; Elastase-2; Elastase 2 neutrophil; Elastase neutrophil expressed; Elastase-2; ELNE_HUMAN; GE antibody Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Leukocyte Elastase Precursor; Medullasin; NE; Neutrophil elastase; Neutrophill elastase; PMN E; PMN Elastase; Polymorphonuclear elastase; SCN1; Serine protease; SERP1.
Cat. No.: HY-187594
CAS No.: 131817-86-2
Target:
Research Areas:
CGS 22745 is a selective and orally active 5-Lipoxygenase inhibitor. CGS 22745 blocks the conversion of Arachidonic acid (HY-109590) to 5-HETE (HY-113434B) and leukotrienes. CGS 22745 inhibits A23187-stimulated LTB4 (HY-107608) formation in whole blood. CGS 22745 inhibits exudate formation and PMN accumulation in Carrageenan (HY-125474)-induced pleurisy. CGS 22745 can be used for research on inflammatory diseases .
Cat. No.: HY-P73298
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Human
Source:
HEK293
Cat. No.: HY-P73808
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78328
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73809
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
CHO
Cat. No.: HY-P700793
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P704792
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMP8; PMNL Collagenase; Prev. CLG1; MMP-8; Matrix Metalloproteinase 8 (Neutrophil Collagenase); PMN Leukocyte Collagenase; Matrix Metalloproteinase-8; Collagenase 2; Neutrophil Collagenase; HNC; Matrix Metallopeptidase 8; PMNL-CL
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
