Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
193 Results for "
c-kit
" in MedChemExpress (MCE) Product Catalog:
Products (193)
193 Results for "c-kit" in MCE Product Catalog:
4
4 Cited Publications
Research Areas:
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC50s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), c-Kit (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .
3
Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively .
3
3 Cited Publications
Cat. No.: HY-P70528
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: kitLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel Factor; Mast Cell Growth Factor; C-kit Ligand; Stem Cell Factor; kit Ligand; DFNA69; SHEP7; kitl; DCUA; KL-1; FPHH; FPH2; WS2F; kit Ligand; SF
Species:
Mouse
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-P70555
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: kitLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel Factor; Mast Cell Growth Factor; C-kit Ligand; Stem Cell Factor; kit Ligand; DFNA69; SHEP7; kitl; DCUA; KL-1; FPHH; FPH2; WS2F; kit Ligand; SF
Species:
Mouse
Source:
HEK293
3
3 Cited Publications
Synonyms: HHGV678 mesylate
Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model .
3
BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy .
3
3 Cited Publications
Synonyms: AC480 Hydrochloride
BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy .
2
2 Cited Publications
Target:
Research Areas:
c-Kit-IN-1 is a potent inhibitor of c-Kit and c-Met with IC50s of <200 nM.
2
2 Cited Publications
Synonyms: GB002; PK10571
Research Areas:
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC50s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .
2
2 Cited Publications
Cat. No.: HY-P80619
Synonyms: kit; SCFR; Mast/stem cell growth factor receptor kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-kit; Tyrosine-protein kinase kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117
2
2 Cited Publications
Synonyms: Quercetin-7-O-β-D-glucopyranoside
Category:
Flavonols Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Derris scandens Ginkgoaceae Extract Ginkgo biloba L. Compositae Extract Disease Research Fields
Target:
1
1 Cited Publications
Synonyms: M4205; IDRX-42
Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC50s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models .
1
1
1 Cited Publications
Cat. No.: HY-18302
CAS No.: 1003311-62-3
Target:
Research Areas:
c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties .
1
1 Cited Publications
Synonyms: STI571-d8; CGP-57148B-d8
1
1 Cited Publications
Synonyms: Bay 57-9352 mesylate
Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and c-Kit inhibitor with IC50s of 6 nM, 4 nM, 15 nM and 1 nM, respectively .
1
1 Cited Publications
Cat. No.: HY-P70757G
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: kitLG; SLF; Prev. MGF; Familial Progressive Hyperpigmentation 2; SCF; Steel Factor; Mast Cell Growth Factor; C-kit Ligand; Stem Cell Factor; kit Ligand; DFNA69; SHEP7; kitl; DCUA; KL-1; FPHH; FPH2; WS2F; kit Ligand; SF
Species:
Human
Source:
HEK293
Synonyms: EVT-8565072; THB335
Research Areas:
Labuxtinib (EVT-8565072; THB335) is a potent dual inhibitor of c-Kit and PDGFR. Labuxtinib exhibits potent inhibitory activity against wild-type c-Kit (IC50 = 0.005 μM). Labuxtinib inhibits SCF-dependent and PDGF-dependent cell proliferation, and blocks the proliferation of cells dependent on c-Kit or PDGFR signaling pathways. In animal models of skin allergy, Labuxtinib depletes skin mast cells and significantly alleviates anaphylactic shock responses. Labuxtinib can be used in research on mast cell-related diseases, respiratory diseases, inflammatory diseases, fibrotic diseases, metabolic diseases, and other related conditions .
Target:
Research Areas:
NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively.
Synonyms: AZD3229
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC50 value of 223.3 nM .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
