311 Results for "

killer

" in MedChemExpress (MCE) Product Catalog:
Products (311)

311 Results for "killer" in MCE Product Catalog:

Cat. No.: HY-P990710
CAS No.: 2738880-26-5
Synonyms: AFM13

Target:  

TNF Receptor

Research Areas:  

Cancer

Acimtamig (AFM13) is a CD30/CD16A bispecific innate cell engager. Acimtamig binds to the CD16A expressed on natural killer (NK) cells and binds to CD30 on CD30-expressing tumor cells, thereby selectively cross-linking tumor and NK cells. Acimtamig can be used for the study of eripheral T-cell lymphoma (PTCL) .
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Cat. No.: HY-P9977A

Target:  

EGFR

Research Areas:  

Cancer

Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .
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Cat. No.: HY-P3586
CAS No.: 859216-15-2
Synonyms: Hunter-killer peptide ao; Prohibitin-targeting peptide 1; prohibitin-TP01; Adipotide
Target:  

Apoptosis

Research Areas:  

Cancer

HKPao (Hunter-killer peptide ao) is a biologically active peptide. HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles .
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Cat. No.: HY-155312
Research Areas:  

Cancer

NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively .
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Cat. No.: HY-P99759
CAS No.: 1622189-43-8
Synonyms: IL-15N72D

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Nogapendekin alfa his tag is an immunostimulant that binds to the IL-2RβγC complex on immune cells. Nogapendekin alfa his tag stimulates the proliferation and activation of natural killer cells and CD8 + T cells, upregulates the expression of granzyme B and perforin, and activates the innate and adaptive immune branches. Nogapendekin alfa his tag forms ALT-803 with IL-15RαSuFc; this complex has an extended biological half-life, improved biodistribution and retention in lymphoid tissues, enhances natural killer cell-mediated rituximab-dependent cellular cytotoxicity, and reduces tumor burden and improves survival when combined with anti-CD20 monoclonal antibody therapy. Nogapendekin alfa his tag can be used in the research of non-Hodgkin's lymphoma .
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Cat. No.: HY-P99226
CAS No.: 2245966-28-1
Synonyms: MEDI7734; VIB7734
Daxdilimab (MEDI7734; VIB7734) is a monoclonal antibody targeting immunoglobulin-like transcript 7 (ILT7) that depletes plasmacytoid dendritic cells and reduces IFN1 production by binding to the plasmacytoid dendritic cell-specific surface molecule ILT7 and recruiting effector natural killer cells. Daxdilimab (MEDI7734; VIB7734) can be used for research on systemic lupus erythematosus, systemic sclerosis, and polymyositis .
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Cat. No.: HY-174736
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CD70 mRNA encodes the human CD70 molecule (CD70) protein, a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. It is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
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Cat. No.: HY-155477
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cancer

Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM). Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 μM .
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Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Target:  

CD38 IFNAR

Research Areas:  

Cancer

Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma .
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Cat. No.: HY-P991136
CAS No.: 3009874-10-3

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Etuptamig is a chimeric monoclonal antibody of immunoglobulin λ-chain-γ1, λ-chain-γ3 targeting human natural killer cell cytotoxicity receptor 1 (NCR1). Etuptamig is promising for research of various cancers .
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Cat. No.: HY-P990905
CAS No.: 2871775-98-1
Synonyms: SAR-443579

Target:  

Interleukin Related

Research Areas:  

Cancer

Bexatamig (SAR-443579) is a trifunctional natural killer cell engager targeting IL-3R α/CD123, NKp46/NCR1/CD335 and Fc gamma RIIIA/CD16a. Bexatamig forms a cytolytic synapse between natural killer cells and CD123-positive tumor cells. By activating natural killer cells to induce tumor cell death, Bexatamig effectively reduces the burden of CD123-positive acute myeloid leukemia (AML) blasts. Bexatamig has been granted FDA Fast Track designation, and is primarily investigated for relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, and high-risk myelodysplastic syndromes .
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Cat. No.: HY-157136
CAS No.: 1799330-91-8
Target:  

CRM1 COX c-Myc Survivin

Research Areas:  

Cancer

LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research .
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Cat. No.: HY-174642
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human IL12A mRNA encodes the human interleukin 12A (IL12A) protein, a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12A is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells.
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Cat. No.: HY-P990719
CAS No.: 2736449-62-8
Synonyms: XmAb24306

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Efbalropendekin Alfa (XmAb24306) is an IL-15/IL-15 receptor alpha complex fused to a heterodimeric Fc domain (IL15/IL15Rα-Fc). Efbalropendekin Alfa increases direct and antibody-dependent cellular cytotoxicity (ADCC)-mediated human natural killer (NK) cell cytotoxicity in vitro .
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Cat. No.: HY-174641
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human IL12B mRNA encodes the human interleukin 12B (IL12B) protein, a subunit of interleukin 12, is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
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Cat. No.: HY-157657
CAS No.: 2260669-34-7
Synonyms: Diphosphatidylglycerol sodium salt; 16:1 Cardiolipin sodium salt; 64:4-CL sodium salt
Cardiolipin (16:1/16:1/16:1/16:1) (Diphosphatidylglycerol; 16:1 Cardiolipin; 64:4-CL ) sodium salt, phospholipid, is a natural killer T (NKT) cells agonist. Cardiolipin (16:1/16:1/16:1/16:1) sodium salt induces increased cytokine (IL-2) production by NKT cell hybridomas. Cardiolipin (16:1/16:1/16:1/16:1) sodium salt can be used for the researches of cancer and immunology .
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Cat. No.: HY-18343
CAS No.: 259199-65-0
Target:  

MDM-2/p53 Apoptosis

Research Areas:  

Cancer

CP-31398 can stabilize the active conformation of p53 and promote p53 activity in cancer cells with either mutant or wild-type p53. In addition, CP-31398 can upregulate p53 target genes, such as p21WAF1/Cip1 and KILLER/DR5. CP-31398 exerts an inhibitory effect on tumor growth .
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Cat. No.: HY-113008BR
CAS No.: 3465-72-3
Synonyms: (E)-Urocanic acid (Standard); trans-UCA (Standard)
trans-Urocanic acid (Standard) is the analytical standard of trans-Urocanic acid. This product is intended for research and analytical applications. trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .
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Cat. No.: HY-RS14796
Research Areas:  

Others

TNFRSF10B Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF10B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-117231
CAS No.: 126869-52-1
Target:  

Others

Research Areas:  

Inflammation/Immunology Cancer

RM 06 is an immunomodulator with a peptidyl hypoxanthine structure. RM 06 significantly reduces the number of lung metastases of melanoma cells in mice after lethal irradiation and bone marrow reconstitution by stimulating the activity of natural killer (NK) cells. RM 06 can be used for research related to melanoma .
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