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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
741 Results for "
tuberculosis
" in MedChemExpress (MCE) Product Catalog:
Products (741)
741 Results for "tuberculosis" in MCE Product Catalog:
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Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect .
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Category:
Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics
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4 Cited Publications
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BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
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4 Cited Publications
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .
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4 Cited Publications
Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide
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Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
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4 Cited Publications
Synonyms: PNU-100480; U-100480; PF-02341272
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Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
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Contezolid (MRX-I), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid (MRX-I) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI) .
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SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM) .
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Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with an IC50 of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis .
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3 Cited Publications
AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane .
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3 Cited Publications
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TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization .
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3 Cited Publications
Synonyms: (-)-Dehydrocostus lactone; Epiligulyl oxide
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2 Cited Publications
Cat. No.: HY-45854
CAS No.: 1645486-93-6
GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC50 of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo .
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2 Cited Publications
Cat. No.: HY-76260
CAS No.: 122547-49-3
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Faropenem sodium is an orally bioavailable penem antibiotic. Faropenem sodium regulates inorganic phosphate transporter Npt1. Faropenem sodium inhibits M. tuberculosis (MIC of 1.3 μg/mL) and B. anthracis .
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2 Cited Publications
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2 Cited Publications
Synonyms: (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone
Category:
Microorganisms Neurological Disease Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics Cancer
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2 Cited Publications
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Cholesterol oxidase, Microorganism (ChOx, Microorganism) (EC 1.1.3.6) is a cholesterol oxidase identified from bacterial sources. Cholesterol oxidase, Microorganism catalyzes the oxidation of cholesterol to 4-cholesten-3-one, while simultaneously reducing oxygen to hydrogen peroxide. Cholesterol oxidase, Microorganism retains its enzymatic activity and exhibits improved catalytic efficiency upon immobilization. Cholesterol oxidase, Microorganism is applicable for cholesterol detection, steroid biotransformation, and research on tuberculosis-related diseases .
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2 Cited Publications
Synonyms: (±)-Norverapamil hydrochloride; D591 hydrochloride
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Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
