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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
188 Results for "
AMC
" in MedChemExpress (MCE) Product Catalog:
Products (188)
188 Results for "AMC" in MCE Product Catalog:
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1 Cited Publications
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Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria .
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1 Cited Publications
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1 Cited Publications
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STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay .
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1 Cited Publications
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ERAP2-IN-1 (compound 61) is an uncompetitive ERAP2 inhibitor. ERAP2-IN-1 specifically inhibits the ERAP2 peptide hydrolysis activity, inhibiting Arg-AMC hydrolysis with an IC50 of 27 μM and model peptide hydrolysis with an IC50 of 44 μM .
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1 Cited Publications
Synonyms: LCA hydroxyamide
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LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .
Cat. No.: HY-D0027
CAS No.: 26093-31-2
Synonyms: Coumarin 120; AMC
Cat. No.: HY-D1705
CAS No.: 2357123-49-8
Cat. No.: HY-P1759
CAS No.: 65147-22-0
Synonyms: Z-FR-AMC
Synonyms: Leu-AMC hydrochloride
Cat. No.: HY-P2618
CAS No.: 2237216-30-5
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Cat. No.: HY-135070
CAS No.: 929903-87-7
Synonyms: Ac-Arg-Leu-Arg-AMC
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Cat. No.: HY-137199
CAS No.: 65147-21-9
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Cat. No.: HY-P11212
CAS No.: 1193634-36-4
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Cat. No.: HY-P4547
CAS No.: 189275-74-9
Synonyms: AC-WEHD-AMC
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a fluorescent peptide caspase-1 substrate. Ac-Trp-Glu-His-Asp-AMC is cleaved by caspase-1, enabling the measurement of caspase-1 proteolytic activity. Ac-Trp-Glu-His-Asp-AMC is cleaved by proinflammatory caspases but not by proapoptotic caspases. Ac-Trp-Glu-His-Asp-AMC requires higher enzyme concentrations to detect active caspase-1 .
Cat. No.: HY-P4425
CAS No.: 201852-70-2
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Cat. No.: HY-P1759A
CAS No.: 70382-26-2
Synonyms: Z-FR-AMC hydrochloride
Cat. No.: HY-P4417
CAS No.: 216757-33-4
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Cat. No.: HY-120957
CAS No.: 862913-13-1
Synonyms: AMC-AA; 7-Amino-4-methyl coumarin-arachidonamide
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AMC Arachidonoyl Amide (AMC-AA; 7-Amino-4-methyl coumarin-arachidonamide) is a fluorescent fatty acid amide substrate used to detect fatty acid amide hydrolase (FAAH) activity. AMC Arachidonoyl Amide releases 7-amino-4-methylcoumarin (AMC) upon hydrolysis by FAAH, producing fluorescence at Ex 360 nm/Em 465 nm, thereby allowing rapid determination of FAAH activity using a cuvette or microplate fluorometer .
Cat. No.: HY-D1652
CAS No.: 292633-16-0
Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
