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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
119 Results for "
S-Transferase
" in MedChemExpress (MCE) Product Catalog:
Products (119)
119 Results for "S-Transferase" in MCE Product Catalog:
Cat. No.: HY-W013754
CAS No.: 24425-56-7
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S-Hexylglutathione is an S-substituted glutathione in which the hydrogen of the thiol has been replaced by a hexyl group. S-Hexylglutathione is also an competitive inhibitor against glutathione-S-transferase. S-Hexylglutathione can be used as an affinity chromatographic ligand for glutathione-S-transferase and glutathione peroxidase .
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Glutathione sulfonate (S-Sulfoglutathione) is a multifunctional bioactive compound that inhibits angiogenesis and tumor growth. Glutathione sulfonate is a competitive inhibitor of glutathione S-transferase and is involved in the detoxification process and the binding of a variety of exogenous and endogenous compounds. Glutathione sulfonate acts in the substrate binding site of Escherichia coli glutathione S-transferase, affecting the catalytic mechanism. The structural characteristics of Glutathione sulfonate contribute to its inhibitory effect by hydrogen bonding in the active center of the enzyme .
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Cat. No.: HY-16124
CAS No.: 158382-37-7
Synonyms: TLK-286; TER286
Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies .
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Ethacrynic acid (Standard) is the analytical standard of Ethacrynic acid. This product is intended for research and analytical applications. Ethacrynic acid (Etacrynic acid) is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice .
Cat. No.: HY-W020788
CAS No.: 98730-04-2
Synonyms: CGA 154281
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Environmental Pollutants Glutathione S-transferase Estrogen Receptor/ERR Pregnane X Receptor (PXR) FXR
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Benoxacor (CGA 154281) is a herbicide safener and xenobiotic metabolism regulator. Benoxacor protects maize from the toxicity of metolachlor mainly by inducing detoxifying enzymes such as Glutathione S-transferase. Benoxacor also activates FXR, PXR and ERRα, and inhibits aromatase (aromatase). However, Benoxacor exhibits potential subacute oral toxicity and a high risk of hepatotoxicity in animal models. Benoxacor induces reactive oxygen species accumulation, interferes with embryonic heart development, and causes increased liver and kidney weights as well as alterations in gut microbiota in mice. Benoxacor can be used in studies related to hepatic steatosis, infertility, breast cancer and developmental toxicity .
Cat. No.: HY-132281
CAS No.: 108664-99-9
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16-Oxokahweol, a Kahweol (HY-N6258) derivative, is a glutathione S-transferase inducer .
Cat. No.: HY-138164
CAS No.: 81760-46-5
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Cafestol palmitate is an orally active diterpene ester. Cafestol palmitate can be isolated from raw coffee beans. Cafestol palmitate enhances the activity of Glutathione S-transferase. Cafestol palmitate downregulates the expression of Akt and VEGFR2. Cafestol palmitate can be used in the research of inflammatory diseases and cardiovascular diseases .
Cat. No.: HY-W024365
CAS No.: 88-32-4
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Cat. No.: HY-170920
CAS No.: 3056059-99-2
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Herbicide safener-4 is a herbicide safener targeting acetolactate synthase (ALS). Herbicide safener-4 competitively binds to the active site of ALS, blocks the binding of Mesosulfuron-methyl (HY-126987), and simultaneously allows substrates to enter for catalytic reactions. Herbicide safener-4 increases the content/activity of glutathione (GSH), glutathione S-transferase (GST), cytochrome P450 monooxygenase (CYP450) and peroxidase (POD) in plants, and decreases the activity of superoxide dismutase (SOD) .
Cat. No.: HY-W013744
CAS No.: 24435-27-6
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S-Octylglutathione is a competitive glutathione S-transferase (GST) inhibitor .
Cat. No.: HY-160875
CAS No.: 920115-54-4
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GST-FH.1 is a GST-FH compound, a complex that produces frequent false positive hits (FH) in the interaction between glutathione S-transferase (GST) and glutathione (GSH) . GST-FH.4 inhibits glutathione S-transferase (GST) activity with an IC50 of 0.32 μM .
Cat. No.: HY-W681867
CAS No.: 88485-37-4
Synonyms: CGA-133205
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Fluxofenim (CGA-133205) is a herbicide safener, with activity against Pyroxasulfone (HY-136633) and Metolachlor (HY-B1871). Fluxofenim enhances the activity of needle glutathione S-transferase (GST) towards the substrate 1-chloro-2,4-dinitrobenzene (CDNB) .
Cat. No.: HY-126752A
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Ophthalmic acid TFA is a ubiquitous metabolite and glutathione modulator, with a Ki of 0.95 mM for glyoxalase I. Ophthalmic acid TFA competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid TFA is applicable in diabetes-related research .
Cat. No.: HY-149419
CAS No.: 2987870-87-9
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GST-IN-1 (compound 16) is a glutathione S-transferase (GST) inhibitor with IC50s of 1.55 μM (sjGST) and 2.02 μM (hGSTM2), respectively.
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Crambene is an orally active cyanide compound isolated from cruciferous vegetables. Crambene has a cancer-preventive effect and induces significant upregulation of quinone reductase and glutathione S-transferase in vitro and in vivo .
Cat. No.: HY-160926
CAS No.: 108664-98-8
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16-Oxocafestol is a diterpene ketone derivative of Cafestol (HY-N6257). 16-Oxocafestol increases the levels of glutathione S-transferase (GST) and tissue sulfhydryl groups in the liver and small intestinal mucosa .
Cat. No.: HY-177695
CAS No.: 2290641-22-2
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GSTO1-IN-5 is a potent and selective glutathione S-transferase omega 1 (GSTO1) inhibitor with an IC50of 0.22 nM. GSTO1-IN-5 can be used for the researches of cancer and inflammation, such as colon cancer .
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GSTP1-1 inhibitor 1 (compound 6b) is an irreversible, long-acting, glutathione S-transferase inhibitor with an IC50 of 21 μM targeting GSTP1-1 . GSTP1-1 is a key tumor suppressor target, and GSTP1-1 inhibitor 1 has potential anticancer activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
