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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
436 Results for "
SRC
" in MedChemExpress (MCE) Product Catalog:
Products (436)
436 Results for "SRC" in MCE Product Catalog:
Synonyms: YN968D1-d8 free base
Cat. No.: HY-170958
Scr-IN-1 (Compound 4e) is a Tyrosine kinase inhibitor. Scr-IN-1 inhibits HCT-116 cells and MIA-PaCa-2 cells with IC50s of 0.16 μM and 1.16 μM, respectively. Scr-IN-1 displays selectivity profile on HCT-116 cells and MIA-PaCa-2 cells with SI > 625 and SI > 86, respectively. Scr-IN-1 induces Apoptosis in HCT-116 colon cancer cell and does not cause any change in the rate of necrotic cells. Scr-IN-1 is a novel SRC kinase inhibitor candidate for HCT-116 cells. Scr-IN-1 is potential for cancer research .
Cat. No.: HY-P706066
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: LYN; Tyrosine-Protein Kinase Lyn; LYN Proto-Oncogene, SRC Family Tyrosine Kinase; P53Lyn; JTK8; P56Lyn; V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog; Tyrosine-Protein Kinase; Lck/Yes-Related Novel Protein Tyrosine Kinase; SAIDV
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701691
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HCK; P59-HCK/P60-HCK; HCK Proto-Oncogene, SRC Family Tyrosine Kinase; P59Hck; Hemopoietic Cell Kinase; P61Hck; JTK9; Tyrosine-Protein Kinase; Tyrosine-Protein Kinase HCK; AIPCV; Hematopoietic Cell Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706102
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SRMS; PTK70; Prev. C20orf148; Tyrosine-Protein Kinase Srms; DJ697K14.1; Chromosome 20 Open Reading Frame 148; SRC-Related Kinase Lacking C-Terminal Regulatory Tyrosine And N-Terminal Myristylation Sites; SRM
Species:
Human
Source:
Sf9 insect cells
S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: 113B7
PDZ1i (113B7) is a inhibitor of MDA-9/Syntenin, with selective binding to the PDZ1 domain. PDZ1i inhibits radiation-induced invasion of glioblastoma (GBM) cells, radiosensitizes GBM cells, and impairs GBM-related signaling pathways (including Src/EphA2, EGFRvIII/FAK, and NF-κB). PDZ1i reduces radiation-induced secretion of invasion-related proteases (MMP-2, MMP-9, ADAM9). PDZ1i shows anti-tumor effects in nude mice bearing intracranial U1242-luc xenografts or GBM xenografts. PDZ1i can be used for the study of glioblastoma (GBM), breast cancer and prostate cancer .
Cat. No.: HY-P701692
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HCK; P59-HCK/P60-HCK; HCK Proto-Oncogene, SRC Family Tyrosine Kinase; P59Hck; Hemopoietic Cell Kinase; P61Hck; JTK9; Tyrosine-Protein Kinase; Tyrosine-Protein Kinase HCK; AIPCV; Hematopoietic Cell Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P70396
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GRB2; Epididymis Secretory Sperm Binding Protein; Growth Factor Receptor Bound Protein 2; Growth Factor Receptor-Bound Protein 3; Growth Factor Receptor-Bound Protein 2; Abundant SRC Homology; SH2/SH3 Adapter GRB2; EGFRBP-GRB2; NCKAP2; MSTP084; Adapter Pr
Species:
Human
Source:
E. coli
Cat. No.: HY-P75665
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With SRC Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P77891
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With SRC Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
Species:
Human
Source:
HEK293
Cat. No.: HY-P77892
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With SRC Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
Species:
Human
Source:
HEK293
Cat. No.: HY-P78268
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With SRC Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P700687
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With SRC Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
Species:
Rat
Source:
HEK293
Target:
Cat. No.: HY-158429
CAS No.: 2836297-26-6
Target:
Research Areas:
PROTAC CYP1B1 degrader-2 is a CYP1B1 PROTAC degrader with a DC50 of approximately 0.1 nM. PROTAC CYP1B1 degrader-2 induces ubiquitination and proteasomal degradation of CYP1B1, and forms a ternary complex with VHL ubiquitin ligase and CYP1B1. PROTAC CYP1B1 degrader-2 inhibits P-gp. PROTAC CYP1B1 degrader-2 inhibits FAK/SRC. PROTAC CYP1B1 degrader-2 exhibits anticancer activity against paclitaxel (HY-B0015)-resistant non-small cell lung cancer. PROTAC CYP1B1 degrader-2 can be used in studies related to non-small cell lung cancer .
Cat. No.: HY-P70109
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With SRC Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
Species:
Human
Source:
HEK293
Cat. No.: HY-P77625
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With SRC Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
Species:
Rhesus Macaque
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
