![Benzo[a]pyrene diol epoxide](https://file.medchemexpress.com/product_pic/hy-w585976.gif "Click to View Benzo[a]pyrene diol epoxide Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
502 Results for "
aromatic
" in MedChemExpress (MCE) Product Catalog:
Products (502)
502 Results for "aromatic" in MCE Product Catalog:
Cat. No.: HY-L0122V
1,122 compounds
Several CNS multi-parameter scoring approaches have been reported: CNS-MPO, CNS-MPO V.2, CNS-TEMPO, which suggesting an algorithm to predict CNS-ike properties of new chemical entities. We have applied these scoring algorithms to select macrocycles satisfying multiple cut-offs and structural desirability criteria. The resulting set consists of 1,122 macrocyclic compounds with CNS-MPO > 4, CNS-MPO.v2 > 4, and CNS-TEMPO < 4 for CNS-related drug discovery and research.
Cat. No.: HY-103084
CAS No.: 2109805-65-2
Target:
Research Areas:
PDE5-IN-1 is an orally active, selective PDE5 inhibitor with an IC50 of 5.6 nM. PDE5-IN-1 forms hydrogen bond interactions with the Q817 residue in the catalytic domain of PDE5, and aromatic π-π stacking interactions with the F820 residue. PDE5-IN-1 exerts anti-cardiac hypertrophy and vasodilatory effects, reduces mean pulmonary arterial pressure and right ventricular hypertrophy index. PDE5-IN-1 can be used in the research of pulmonary arterial hypertension .
Cat. No.: HY-135081
CAS No.: 261766-23-8
Synonyms: N-4AIA
N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.1 N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.
Cat. No.: HY-136913R
CAS No.: 69617-84-1
Synonyms: (Rac)-Betuligenol (Standard)
Research Areas:
(Rac)-Rhododendrol (Standard) ((Rac)-Betuligenol (Standard)) is the analytical standard of (Rac)-Rhododendrol (HY-136913). This product is intended for research and analytical applications. (Rac)-Rhododendrol ((Rac)-Betuligenol) is an aromatic compound with pro-oxidant activity. (Rac)-Rhododendrol may be useful in the suppression of liver diseases. (Rac)-Rhododendrol can be toxic to melanocytes, leading to cell death. The metabolite of (Rac)-Rhododendrol, RD-quinone, is cytotoxic and causes enzyme inactivation and endoplasmic reticulum stress by binding to thiol proteins. (Rac)-Rhododendrol-derived melanin exhibits potent pro-oxidant activity and may cause oxidative stress .
Cat. No.: HY-E72103
Target:
Research Areas:
Human CYP1A1, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 1A1, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP1A1 is a human cytochrome P450 subtype belonging to the CYP1 family, as well as a major metabolic enzyme. Its expression is concentrated in tissues such as lung, breast, placenta and endometrium, and it can metabolize polycyclic aromatic hydrocarbons and estrogens into carcinogenic intermediates with DNA-damaging activity .
Cat. No.: HY-N0761A
CAS No.: 25522-33-2
Synonyms: trans-3-Hydroxy-4-methoxycinnamic acid
Cat. No.: HY-W002114
CAS No.: 2374-03-0
Cat. No.: HY-W006416R
CAS No.: 488-23-3
Target:
Research Areas:
1,2,3,4-Tetramethylbenzene (Standard) is the analytical standard substance of 1,2,3,4-Tetramethylbenzene. This product is used for research and analytical applications. 1,2,3,4-Tetramethylbenzene is an aromatic hydrocarbon. 1,2,3,4-Tetramethylbenzene can serve as a molecular marker indicating the input of photosynthetic sulfur bacteria (especially green sulfur bacteria) in ancient sedimentary environments, reflecting the static marine environment of the source rock deposition. 1,2,3,4-Tetramethylbenzene can also be used as a drug intermediate.
Cat. No.: HY-W010155R
CAS No.: 526-55-6
Synonyms: Indole-3-ethanol (Standard)
Cat. No.: HY-W011727R
CAS No.: 853645-22-4
Synonyms: Pyridoxal phosphate hydrate (Standard)
Cat. No.: HY-W016103R
CAS No.: 86-48-6
Cat. No.: HY-W035904
CAS No.: 539-80-0
Synonyms: Cycloheptatrienone
Category:
Ketones, Aldehydes, Acids Other Diseases Plants Other Families Extract Disease Research Fields
Target:
Cat. No.: HY-W114420
CAS No.: 17028-03-4
Target:
Research Areas:
3-Methyl-L-tyrosine is a derivative of L-Tyrosine (HY-N0473). Structurally, 3-Methyl-L-tyrosine features a methyl modification at the third position of the aromatic ring of L-Tyrosine. As a substrate for the protein tyrosine kinase Csk, 3-Methyl-L-tyrosine's relative catalytic efficiency (kcat/Km) is 38% of L-Tyrosine, indicating that the methyl modification impacts the processing efficiency of Gsk significantly. 3-Methyl-L-tyrosine helps to deepen the understanding of Gsk's molecular recognition mechanisms of its substrates, which is crucial for developing specific inhibitors targeting Gsk .
Cat. No.: HY-W585976
CAS No.: 58917-67-2
Target:
Research Areas:
Benzo[a]pyrene diol epoxide is a carcinogen present in tobacco smoke as well as in environmental pollution. Benzo[a]pyrene diol epoxide is a metabolite of benzo[a]pyrene (BaP) , which is polycyclic aromatic hydrocarbon (PAH) . Benzo[a]pyrene diol epoxide induces esophageal carcinogenesis. Benzo[a]pyrene diol epoxide may act to induce activation of ERKs and p38 MAPK marked by an increased level of phosphorylation of both the ERKs and p38 MAPK which corresponds with the increased activation of both kinases as evidenced by increased phsosphorylation of their substrates Elk-1 and ATF-2, respectively.
Cat. No.: HY-W738270
CAS No.: 1173022-44-0
Synonyms: 3,4-Dimethoxy[7-13C]-benzaldehyde
Cat. No.: HY-B0863S5
CAS No.: 2732154-65-1
Cat. No.: HY-N0060BR
CAS No.: 537-98-4
Synonyms: (E)-Coniferic acid (Standard)
Cat. No.: HY-N16431
CAS No.: 165133-85-7
Category:
Synonyms: 3-DHS (Standard); 5-Dehydroshikimic acid (Standard)
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
