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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
70 Results for "
corpus cavernosal strips
" in MedChemExpress (MCE) Product Catalog:
Products (70)
70 Results for "corpus cavernosal strips" in MCE Product Catalog:
Cat. No.: HY-12956S2
Synonyms: Prostaglandin F2α-13C5; PGF2α-13C5
Cat. No.: HY-12956AR
CAS No.: 38562-01-5
Synonyms: Prostaglandin F2α tromethamine salt (Standard); PGF2α THAM (Standard); Prostaglandin F2α THAM (Standard)
Cat. No.: HY-115381
CAS No.: 110657-98-2
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Lipoxin A5 is an eicosapentaenoic acid derived from pig white blood cells. Lipoxin A5 slowly contracted the guinea pig lung parenchymal strips with a contractile force similar to that of LXA4 and LXB4.2, but LXA5 did not have the vasodilating effect on the aortic smooth muscle shown by LXA4 and LXB4.2 .
Cat. No.: HY-W587689
CAS No.: 120293-93-8
Synonyms: Juvenile hormone III bisepoxide; Juvenile hormone bisepoxide; JHB3
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Juvenile hormone B 3 (Juvenile hormone III bisepoxide)(mixture of diastereomers) is a sesquiterpenoid hormone. Juvenile hormone B 3 can be isolated from corpus allatum (CA) of high dipterans like the fruitfly and Drosophila melanogaster. JHB3 has anti-metamorphic activity and induces Kr-h1 expression by directly interacting with juvenile hormone (JH) receptors (Met and Gce). Juvenile hormone B 3 can be used for insect lethality research .
Cat. No.: HY-123468A
CAS No.: 92564-08-4
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HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .
Cat. No.: HY-134971
CAS No.: 893426-98-7
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AE9C90CB is an M3 muscarinic receptor (mAChR) antagonist and M2 muscarinic receptor ligand (human pKi values of 9.9 and 8.6, respectively). AE9C90CB binds to the M3 receptor and produces an insurmountable antagonism of Carbamoylcholine chloride (HY-B1208)-induced bladder strip contraction, thereby inhibiting the elevation of intravesical pressure and salivation, and exhibits functional selectivity for the bladder relative to the salivary glands. AE9C90CB can be used in the study of overactive bladder .
Cat. No.: HY-114797
CAS No.: 261769-44-2
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PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction .
Cat. No.: HY-RS28466
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Strip2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Strip2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Fenharmane is a serotonin 2B (5HT2B) receptor antagonist. Fenharmane blocks serotonin-induced contractions mediated by 5HT2B receptors in isolated strips of rat fundus smooth muscle .
Cat. No.: HY-44667
CAS No.: 35231-36-8
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Deacetylmoxisylyte is an orally active metabolite in plasma of the prodrug Moxisylyte. Deacetylmoxisylyte exhibits similar affinity and selectivity for rabbit corpus cavernosum and urethra. Deacetylmoxisylyte has IC50 values of 400 and 1200 nM for alpha-1 and alpha-2 adrenoceptors .
Cat. No.: HY-P12356
CAS No.: 843663-78-5
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C16-VVVAAAEEE is a peptide amphiphile and biodegradable nanofiber scaffold that self-assembles into a hydrogel upon calcium ion triggering, enabling delivery of Sonic hedgehog protein to corpus cavernosum smooth muscle with prolonged release and without eliciting a significant immune response. C16-VVVAAAEEE is used in research on erectile dysfunction .
Cat. No.: HY-D3206
CAS No.: 1860808-05-4
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NSC-2888 is a Rho kinase II (ROCK-II) inhibitor with an IC50 of 8.4 nM against human targets. NSC-2888 inhibits enzymatic activity by binding to active site amino acids via hydrogen bonds and hydrophobic interactions. NSC-2888 induces relaxation of pre-contracted rat aortic strips. NSC-2888 can be used in research related to hypertension .
Cat. No.: HY-182680
CAS No.: 136440-42-1
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Manoalogue is an irreversible secretory phospholipase A2 (sPLA2) inhibitor. Manoalogue covalently modifies K94 of bee venom phospholipase A2 (bvPLA2) to inactivate the enzyme and shows selective inhibition on bvPLA2. Manoalogue can suppress PLA2-mediated contractions of guinea pig lung pleural strips. Manoalogue is used for sPLA2 mechanism and respiratory physiology research .
Cat. No.: HY-Y0306
CAS No.: 12124-97-9
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Ammonium bromide is an inorganic electrolyte additive used in halogen-free magnesium-sulfur battery electrolytes, which serves dual functions as a regulator and a resistance-reducing agent. Ammonium bromide effectively optimizes the interfacial reaction kinetics of batteries by guiding the uniform deposition of magnesium, reducing the activation energy for magnesium ion transport, and decreasing the stripping/deposition overpotential. Ammonium bromide significantly enhances the cycle life and initial discharge capacity of magnesium-sulfur batteries .
Cat. No.: HY-182370
CAS No.: 3076612-97-7
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TKP-5 is a PROTAC protein degrader targeting BRD4. TKP-5 can binds to BRD2, BRD3, BRD4 and BRDT, with Kd values of 150 nM, 100 nM and 150 nM for the first three proteins respectively. TKP-5 inhibits the production of thymic stromal lymphopoietin and suppresses the expression of IL-33 mRNA. TKP-5 is applicable to studies related to tape-stripping induced skin injury .
Cat. No.: HY-180334
CAS No.: 120004-07-1
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S-312 is a calcium antagonist with a bicyclic dihydrothienopyridine structure. S-312 can relax the helical strips of various isolated rabbit arteries procontracted with high potassium depolarizaiton. S-312 competitively imhibits calcium-induced contractions in depolarized basilar and femoral arteries. S-312 increases AV nodal conduction time in Langenedorff-perfused isolated rabbit hearts. S-312 exhibits vasculoselectivity, particularly for cerebral vessel .
Cat. No.: HY-182515
CAS No.: 112682-32-3
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U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases .
Cat. No.: HY-120473A
CAS No.: 1192347-42-4
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TAK-259 hydrochloride is an orally active α1D-adrenergic receptor antagonist with a Ki value of 1.1 nM for human α1D-adrenergic receptors. TAK-259 hydrochloride can inhibit the contraction of isolated bladder strips in rats with bladder outlet obstruction, reduce non-voiding bladder contractions, and improve urinary frequency symptoms. TAK-259 hydrochloride can be used in research related to overactive bladder .
Cat. No.: HY-W698583A
CAS No.: 214211-69-5
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BNN5Na is a guanylate cyclase activator and vasorelaxant inducer. BNN5Na undergoes photolytic uncaging to release nitric oxide. BNN5Na remains stable in pH 7.4 phosphate buffer at 37°C for over 1 day in the dark and does not react noticeably with cysteine under these conditions. BNN5Na is water-soluble but membrane-impermeant, remaining in extracellular aqueous compartments. BNN5Na shows no cytotoxicity toward rat aortic strip contractile apparatus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
