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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
72 Results for "
ABL1
" in MedChemExpress (MCE) Product Catalog:
Products (72)
72 Results for "ABL1" in MCE Product Catalog:
Cat. No.: HY-14979A
CAS No.: 1237536-18-3
Research Areas:
ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers [1].
Cat. No.: HY-162489
Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC50=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia [1].
Cat. No.: HY-13072B
CAS No.: 1145859-64-8
Synonyms: AS-703569 benzoate; R-763 benzoate
Cenisertib (AS-703569) benzoate is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib benzoate induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib benzoate inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia [1] .
Cat. No.: HY-15728S
CAS No.: 2754051-83-5
Synonyms: IY-5511-d6
Cat. No.: HY-155112
CAS No.: 2713553-88-7
Target:
Research Areas:
Antiproliferative agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC50s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation [1].
Cat. No.: HY-P706226
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogene 1, Receptor Tyrosine Kinase; BCR-ABL1 P190; Abelson Tyrosine-Protein Kinase 1; ABL1 Protein; Tyrosine-Protein Kinase ABL1; BCR-ABL; Proto-Oncogene C-ABL; Bcr/ABL; Abelson Murine Leukemia Viral Oncogene Homolog 1; CHDSKM; ABL Protooncogene 1 Nonreceptor Tyrosine Kinase; C-ABL1; C-ABL Oncogene 1, Non-Receptor Tyrosine Kinase; V-ABL; Proto-Oncogene Tyrosine-Protein Kinase ABL1; C-ABL; ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase; BCR/ABL1 Fusion Protein E3a1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702716
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogen
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71685
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogen
Species:
Human
Source:
E. coli
Cat. No.: HY-P77308
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogen
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705723
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogen
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705725
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogen
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-P705724
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogen
Species:
Human
Source:
sf9 insect cells
Cat. No.: HY-184100S
CAS No.: 2767305-95-1
Synonyms: Relcobatinibum
Cat. No.: HY-P706237
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ABL1; BCR/ABL1 E1a2 Fusion Protein; Prev. ABL; Bcr/C-ABL Oncogene Protein; JTK7; Chimeric BCR::ABL1 Protein; P150; BCR::ABL1 Fusion Protein; C-ABL; BCR/ABL E8a2 Fusion; V-ABL Abelson Murine Leukemia Viral Oncogene Homolog 1; BCR/ABL1 Fusion; C-ABL Oncogene 1, Receptor Tyrosine Kinase; BCR-ABL1 P190; Abelson Tyrosine-Protein Kinase 1; ABL1 Protein; Tyrosine-Protein Kinase ABL1; BCR-ABL; Proto-Oncogene C-ABL; Bcr/ABL; Abelson Murine Leukemia Viral Oncogene Homolog 1; CHDSKM; ABL Protooncogene 1 Nonreceptor Tyrosine Kinase; C-ABL1; C-ABL Oncogene 1, Non-Receptor Tyrosine Kinase; V-ABL; Proto-Oncogene Tyrosine-Protein Kinase ABL1; C-ABL; ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase; BCR/ABL1 Fusion Protein E3a1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-182792
CAS No.: 2412966-86-8
Synonyms: TERN-701
Embibatinib (TERN-701) is an orally active and allosteric BCR-ABL1 tyrosine kinase inhibitor targeting the myristoyl pocket. Embibatinib exhibits an IC50 of 0.38 nM against ABL1 wild-type enzyme. Embibatinib can be used for the study of chronic myeloid leukemia (CML) [1].
Cat. No.: HY-185916
CAS No.: 2412969-11-8
BCR-ABL-IN-14 is a tyrosine kinase inhibitor targeting BCR-ABL1, ABL1 and ABL2. BCR-ABL-IN-14 inhibits chronic myeloid leukemia cells. It is applicable to research related to chronic myeloid leukemia, acute myeloid leukemia and acute lymphoblastic leukemia [1].
Cat. No.: HY-131571
CAS No.: 1613168-52-7
Multi-kinase-IN-15 is an orally active multi-kinase inhibitor. Multi-kinase-IN-15 inhibits the kinase activity of MNK1, MNK2, ABL1, ABL1 T315I, FLT3, VEGFR2, RET, cKIT, FGFR2, PDGFRα, and PDGFRβ. Multi-kinase-IN-15 dose-dependently reduces phosphorylation of eIF4E and phosphorylated Crkl in tumor cells, and decreases phosphorylation of eIF4E in tumor tissues. Multi-kinase-IN-15 inhibits tumor growth. Multi-kinase-IN-15 can be used for research on chronic myeloid leukemia [1].
Cat. No.: HY-104010AR
CAS No.: 2119669-71-3
Synonyms: ABL001 hydrochloride (Standard)
Target:
Research Areas:
Asciminib hydrochloride (Standard) is the analytical standard of Asciminib hydrochloride (HY-104010A). This product is intended for research and analytical applications. Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
