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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
216 Results for "
CYP1
" in MedChemExpress (MCE) Product Catalog:
Products (216)
216 Results for "CYP1" in MCE Product Catalog:
Cat. No.: HY-W472509
CAS No.: 73804-65-6
Synonyms: 11-Hydroxy-5,8,12,14-eicosatetraenoic acid
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11-HETE (11-Hydroxy-5,8,12,14-eicosatetraenoic acid) is the activator for cytochrome P450. 11-HETE upregulates the mRNA expressions of CYP1B1, CYP1A1, CYP4A11, CYP4F11, and CYP4F2, induces cell hypertrophy in RL-14 cell, and exhibits potential to be used in cardiovascular diseases [1].
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Rutaceae Extract Human Gut Microbiota Metabolites Flavonoids Citrus limon (L.) Burm. F. Plants Endogenous metabolite Disease Research Fields Cancer
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Cat. No.: HY-175836
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CYP1B1-IN-12 is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 6.05 nM. CYP1B1-IN-12 demonstrates remarkable selectivity, exceeding 1600-fold and 16,000-fold over CYP1A1 and CYP1A2, respectively. CYP1B1-IN-12 can enhance Paclitaxel (HY-B0015)-mediated apoptosis and restore Paclitaxel sensitivity in A549/Taxol-resistant cells. CYP1B1-IN-12 can inhibit the epithelial-mesenchymal transition process and reduce cells migration and invasion. CYP1B1-IN-12 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) [1].
Cat. No.: HY-152196
CAS No.: 176442-56-1
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CYP1B1-IN-5 (Compound 6q) is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 4.7 nM [1].
Cat. No.: HY-118216
CAS No.: 55179-31-2
Synonyms: Biloxazol
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Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an CYP1A1, CYP2B, and CYP3A inducer in vivo and an CYP1A inhibitor in vitro [1] .
Cat. No.: HY-RS03441
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CYP1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N0922
CAS No.: 20697-20-5
Synonyms: DL-Methysticin; (±)-Methystici
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Equilenin is a B-ring unsaturated estrogen discovered in pregnant mare urine and is one of the major components of Premarin, a drug commonly used for estrogen replacement therapy. Equilenin binds to estrogen receptors in the body and exerts effects similar to endogenous estrogens. Equilenin weakly binds to and activates the aryl hydrocarbon receptor (AhR) to induce CYP1A1 expression. Equilenin exhibits high affinity for sex hormone-binding globulin (SHBG/SBP) and is metabolized by CYP1A1/1B1 to 4-hydroxy and 17β-dihydro derivatives. Equilenin is used in breast cancer-related research [1] .
Cat. No.: HY-N6264
CAS No.: 264624-38-6
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Triterpenes Terpenoids Metabolic Disease Plants Cimicifuga foetida Linn. Cimicifuga racemosa (L.) Nutt. Disease Research Fields Ranunculaceae Extract
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Synonyms: Norizalpinin (Standard); 3,5,7-Trihydroxyflavone (Standard)
Cat. No.: HY-148595
CAS No.: 1422527-87-4
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CYP1A1-IN-2 (Compound 14) is a competitive inhibitor of CYP1A1 (Ki: 1.4 μM). CYP1A1-IN-2 exhibits potent antimitotic activity and arrests cell in the G2/M phase. CYP1A1-IN-2 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells [1].
Cat. No.: HY-152079
CAS No.: 2872575-51-2
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CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways [1].
Cat. No.: HY-E72094
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Human CYP1A2, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 1A2, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP1A2 is a human cytochrome P450 subtype belonging to the CYP1 family, as well as a major metabolic enzyme. Its expression is centered in the human liver, and it can activate procarcinogens including aromatic heterocyclic amines and polycyclic aromatic hydrocarbons [1].
Cat. No.: HY-174425
CAS No.: 3077254-39-5
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CYP1B1-IN-9 is a highly selective and competitive CYP1B1 Inhibitor with IC50 values of 1.48 nM, > 100 μM, and > 80 μM for CYP1B1, CYP1A1, and CYP1A2, respectively. CYP1B1-IN-9 significantly inhibits the migration and invasion of A549/T cells. CYP1B1-IN-9 has the ability to resensitize Paclitaxel (HY-B0015)-resistant cells, and good metabolic stability and safety, and shows favorable pharmacokinetic parameters. CYP1B1-IN-9 can be used for the study of tumor-drug resistance [1].
Cat. No.: HY-174333
CAS No.: 3065926-17-9
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CYP1A1-IN-1 (Compound 47) is a small-molecule cytochrome P4501A1 (CYP1A1) inhibitor. CYP1A1-IN-1 reduces the bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 is promising for research of sepsis caused by multidrug-resistant (MDR) bacteria [1].
Cat. No.: HY-175760
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CYP1B1-IN-11 (Compound M2) is a selective CYP1B1 inhibitor with an IC50 of 0.00605 pM. CYP1B1-IN-11 effectively reverses DMBA (HY-W011845)-induced Paclitaxel (HY-B0015) resistance and CYP1B1-IN-11 suppresses tumor cells invasion and migration. CYP1B1-IN-11 can be used for tumor drug resistance research [1].
Cat. No.: HY-162051
CAS No.: 2952712-68-2
Cat. No.: HY-161403
CAS No.: 3052218-49-9
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CYP1B1-IN-8 (Compound 14b) is a CYP1B1 inhibitor (IC50: 4.14 × 10 –5 nM). CYP1B1-IN-8 reduces the resistance in A549 cells to Paclitaxel (HY-B0015), and inhibits cell migration and invasion [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
