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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
116 Results for "
CYP2D6
" in MedChemExpress (MCE) Product Catalog:
Products (116)
116 Results for "CYP2D6" in MCE Product Catalog:
Target:
Research Areas:
Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist Promethazine (HY-B1296). It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6.
Cat. No.: HY-146177
CAS No.: 2531281-25-9
Target:
Research Areas:
CYP3A4 enzyme-IN-1 (compound 59) is a potent antibacterial agent, with a MIC of 1 μg/mL for MRSA. CYP3A4 enzyme-IN-1 exhibits low to moderate inhibitory effects on CYP1A2, CYP2E1, CYP2D6, and CYP3A4 enzymes .
Cat. No.: HY-16718A
CAS No.: 1044535-61-6
Synonyms: PF-00251802 hydrochloride
Research Areas:
Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis .
Cat. No.: HY-W140208
CAS No.: 2404-87-7
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Research Areas:
3-Phenylthiophene (Compound 25) is a CYP2A6 inhibitor with a Ki value of 3.3 μM. The Ki values for CYP2E1, CYP2B6, CYP2C9, and CYP2C19 are 9.7, 14, 112, and 107 μM respectively. It shows no significant inhibition on CYP3A4 and CYP2D6. 3-Phenylthiophene can be used in smoking cessation research .
Cat. No.: HY-12946A
CAS No.: 1198784-97-2
Research Areas:
BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM . BI 653048 phosphate inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM) . BI 653048 phosphate is extracted from patent WO2005028501A1 (Compound 103), is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus .
Cat. No.: HY-B0773
CAS No.: 217797-14-3
Synonyms: BRL29060 mesylate
Target:
Cytochrome P450 5-HT Receptor NO Synthase Apoptosis Serotonin Transporter Estrogen Receptor/ERR
Research Areas:
Paroxetine (BRL29060) mesylate is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine mesylate inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine mesylate is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine mesylate is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions .
Research Areas:
Melperone hydrochloride is a butyrophenone with atypical antipsychotic properties. Melperone hydrochloride is a multireceptor antagonist with Kds of 102 nM, 180 nM, 180 nM, and 150 nM for 5-HT2A, dopamine D2, α1-adrenergic, and α2-adrenergic receptors, respectively. Melperone hydrochloride has weak binding to histamine H1, 5-HT2C, 5-HT1A, 5-HT1D, and muscarinic receptors, with Kd values of 580 nM, 2100 nM, 2200 nM, 3400 nM, >10000 nM, respectively. Melperone hydrochloride is also a CYP2D6 inhibitor. Melperone hydrochloride can be used for the study of schizophrenia, and agitation in the elderly .
Cat. No.: HY-B2169S2
CAS No.: 1219798-80-7
Cat. No.: HY-N1483A
CAS No.: 618094-85-2
Target:
Synonyms: (-)-Cephaeline dihydrochloride (Standard); NSC 32944 (Standard)
Target:
Cat. No.: HY-N2425R
CAS No.: 86831-54-1
Cat. No.: HY-W740630
CAS No.: 102335-57-9
Target:
Research Areas:
8-Hydroxy mirtazapine is a metabolite of the antidepressant Mirtazapine (HY-B0352). 8-Hydroxy mirtazapine is formed from mMirtazapine by the cytochrome P450 (CYP) isoform CYP2D6.
Cat. No.: HY-Z2493
CAS No.: 573691-09-5
Target:
Research Areas:
Aripiprazole N-oxide is a metabolite of the atypical antipsychotic Aripiprazole (HY-14546). Aripiprazole N-oxide is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4.
Cat. No.: HY-113575
CAS No.: 1008531-60-9
Synonyms: OPC-14857 hydrochloride; DM-14857 hydrochloride
Target:
Research Areas:
Dehydroaripiprazole (OPC-14857) hydrochloride is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole hydrochloride. Dehydroaripiprazole hydrochloride has with antipsychotic activity equivalent to Aripiprazole .
Cat. No.: HY-W702646
CAS No.: 352233-14-8
Target:
Research Areas:
Hydroxymethyl tolperisone hydrochloride is a metabolite of Tolperisone (HY-B1139A). Hydroxymethyl tolperisone hydrochloride is formed from tolperisone primarily by the cytochrome P450 (CYP) isoform CYP2D6 and to a lesser extent by CYP2C19 and CYP1A2.
Cat. No.: HY-W803860
CAS No.: 86383-21-3
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Research Areas:
N-Depropylpropafenone is an active metabolite of Propafenone (HY-B0432), generated through the CYP450 enzyme system (mainly CYP2D6). It functions by blocking sodium ion channels, slowing myocardial conduction and exhibiting certain antiarrhythmic effects .
Cat. No.: HY-105124AR
CAS No.: 60398-91-6
Synonyms: Ro 3-4787 hydrochloride (Standard)
Research Areas:
Bufuralol (hydrochloride) (Standard) is the analytical standard of Bufuralol (hydrochloride). This product is intended for research and analytical applications. Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate .
Cat. No.: HY-100665S
CAS No.: 2749328-53-6
Synonyms: OPC-14857-d8; DM-14857-d8
Cat. No.: HY-N0598R
CAS No.: 53963-43-2
Synonyms: 20(S)-Ginsenoside F1 (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
