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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
217 Results for "
MCL-1
" in MedChemExpress (MCE) Product Catalog:
Products (217)
217 Results for "MCL-1" in MCE Product Catalog:
Cat. No.: HY-16695
CAS No.: 509102-00-5
Synonyms: Inhibitor of MCL-1
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MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).
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MCL-1/BCL-2-IN-2 is a Mcl-1 and Bcl-2 inhibitor with IC50 values of 5.4 and 7.66 μM. MCL-1/BCL-2-IN-2 is applicable to the research of Mcl-1-dependent cancers [1].
Cat. No.: HY-128360
CAS No.: 2351218-88-5
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dMCL1-2 is a potent, selective MCL1 PROTAC degrader based on a Cereblon ligand, with a KD value of 30 nM for binding to MCL1. dMCL1-2 induces ubiquitination and degradation of MCL1. dMCL1-2 degrades MCL1, cleaves Caspase-3, and induces Apoptosis. dMCL1-2 can be used in research related to multiple myeloma [1].
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Mcl-1 inhibitor 17 is a Mcl-1 protein inhibitor. Mcl-1 inhibitor 17 can be used for the research of cancer and other diseases [1].
Cat. No.: HY-129702
CAS No.: 2163793-56-2
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MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor [1].
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MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively [1].
Cat. No.: HY-13408
CAS No.: 66389-74-0
Synonyms: Apogossypol; NSC736630
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(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.
Cat. No.: HY-169172
CAS No.: 3097167-82-0
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Bfl-1-IN-5 is a covalent and selective Bfl-1 inhibitor with an IC50 of 22 nM. Bfl-1-IN-5 shows selectivity for Bfl-1 over Bcl-xl, Bcl-2 and Mcl-1. Bfl-1-IN-5 induces caspase-3/7 activation, reduces the viability of Bfl-1-expressing lymphoma cells in combination with an Mcl-1 inhibitor, and binds covalently to intracellular Bfl-1. Bfl-1-IN-5 can be used for lymphoma research [1].
Cat. No.: HY-16669
CAS No.: 713492-66-1
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Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 µM).
Voruciclib hydrochloride is an orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. Voruciclib hydrochloride potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib hydrochloride represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) [1].
Cat. No.: HY-100741A
Purity: 98.54%
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(S,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1 [1].
Synonyms: XMH95
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NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the Mcl-1 protein, and inhibits Mcl-1 expression through down-regulation of Wnt signaling proteins. NSC260594 can also recognize G9-G10-A11-G12 RNA tetraloop of HIV and prevent the binding of the Gag protein within the 5’-UTR. NSC260594 inhibits tumor growth, and can be used for research of Triple-negative breast cancers (TNBCs) [1].
Cat. No.: HY-148203
CAS No.: 1883727-31-8
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Mcl-1 inhibitor 9 (example 2) is a myeloid cell leukemia 1 (Mcl-1) inhibitor with IC50 value of 0.21889 nM. Mcl-1 inhibitor 9 shows anti-tumor activity [1].
Cat. No.: HY-RS08230
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MCL1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163681
CAS No.: 2388470-64-0
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Zamzetoclax (compound 1) is a potential Mcl-1 inhibitor [1].
Cat. No.: HY-101533A
CAS No.: 2143010-83-5
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AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay.
Cat. No.: HY-100741C
Purity: 99.32%
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(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1 [1].
Cat. No.: HY-145826
CAS No.: 2388471-31-4
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Mcl-1 inhibitor 8 is a MCL-1 inhibitor, example 228, extracted from patent WO2019222112 [1].
Cat. No.: HY-145825
CAS No.: 2417463-87-5
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Mcl-1 inhibitor 7 is a potent Mcl-1 inhibitor, example 35, extracted from patent WO2020097577A [1].
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AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
