2. Others
  3. Others
  4. (R,R)-S63845

(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1.

For research use only. We do not sell to patients.

(R,R)-S63845 Chemical Structure

(R,R)-S63845 Chemical Structure

Size Price Stock Quantity
1 mg USD 60 In-stock
5 mg USD 120 In-stock
10 mg USD 180 In-stock
25 mg USD 350 In-stock
50 mg USD 560 In-stock
100 mg USD 890 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R,R)-S63845:

(R,R)-S63845 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1[1].

Molecular Weight

829.26

Formula

C39H37ClF4N6O6S
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC([C@H](OC1=C2[C@@]([C@@]3=C(C)C(Cl)=C(OCCN4CCN(CC4)C)C=C3)=C(SC2=NC=N1)C5=CC=C(O5)F)CC6=C(OCC7=CC=NN7CC(F)(F)F)C=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (361.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2059 mL 6.0295 mL 12.0589 mL
5 mM 0.2412 mL 1.2059 mL 2.4118 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2059 mL 6.0295 mL 12.0589 mL 30.1474 mL
5 mM 0.2412 mL 1.2059 mL 2.4118 mL 6.0295 mL
10 mM 0.1206 mL 0.6029 mL 1.2059 mL 3.0147 mL
15 mM 0.0804 mL 0.4020 mL 0.8039 mL 2.0098 mL
20 mM 0.0603 mL 0.3015 mL 0.6029 mL 1.5074 mL
25 mM 0.0482 mL 0.2412 mL 0.4824 mL 1.2059 mL
30 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0049 mL
40 mM 0.0301 mL 0.1507 mL 0.3015 mL 0.7537 mL
50 mM 0.0241 mL 0.1206 mL 0.2412 mL 0.6029 mL
60 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5025 mL
80 mM 0.0151 mL 0.0754 mL 0.1507 mL 0.3768 mL
100 mM 0.0121 mL 0.0603 mL 0.1206 mL 0.3015 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(R,R)-S63845 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-S63845OthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(R,R)-S63845
Cat. No.:
HY-100741C
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.