(R,R)-S63845
Based on 1 Customer Validation
(R,R)-S63845 is the isomer of S63845 (HY-100741), and can be used as an experimental control. S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1.
For research use only. We do not sell to patients.
- Purity: 99.32%
- Formula: C39H37ClF4N6O6S
- Molecular Weight:829.26
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Blood Cancer Compound Library
HY-L079
-
Mitochondria-Targeted Compound Library
HY-L089
-
Anti-Hematopathy Compound Library
HY-L171
-
Mitophagy Compound Library
HY-L180
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| B-lymphoblastic leukemic cell line | IC50 |
<100 nM
Compound: S63845
|
Anticancer activity against human T-lymphoblastic leukemic cell line assessed as reduction in cell viability
Anticancer activity against human T-lymphoblastic leukemic cell line assessed as reduction in cell viability
|
[PMID: 33253879] |
| Leukemia cell | IC50 |
<100 nM
Compound: S63845
|
Anticancer activity against human leukemia cell assessed as reduction in cell viability
Anticancer activity against human leukemia cell assessed as reduction in cell viability
|
[PMID: 33253879] |
| Lymphoma cell line | IC50 |
<100 nM
Compound: S63845
|
Anticancer activity against human Lymphoma cell line assessed as reduction in cell viability
Anticancer activity against human Lymphoma cell line assessed as reduction in cell viability
|
[PMID: 33253879] |
| NCI-H929 | GI50 |
<10 nM
Compound: S63845
|
Antiproliferative activity against Mcl1-sensitive human NCI-H929 cells
Antiproliferative activity against Mcl1-sensitive human NCI-H929 cells
|
[PMID: 30929420] |
| NCI-H929 | IC50 |
6 nM
Compound: 5e
|
Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 33146521] |
Chemical Information
-
Appearance Solid
-
Molecular Weight 829.26
-
Formula C39H37ClF4N6O6S
-
Color Light brown to yellow
-
SMILES
OC([C@H](OC1=C2[C@@]([C@@]3=C(C)C(Cl)=C(OCCN4CCN(CC4)C)C=C3)=C(SC2=NC=N1)C5=CC=C(O5)F)CC6=C(OCC7=CC=NN7CC(F)(F)F)C=CC=C6)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (120.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (255 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2059 mL | 6.0295 mL | 12.0589 mL | 30.1474 mL |
| 5 mM | 0.2412 mL | 1.2059 mL | 2.4118 mL | 6.0295 mL | |
| 10 mM | 0.1206 mL | 0.6029 mL | 1.2059 mL | 3.0147 mL | |
| 15 mM | 0.0804 mL | 0.4020 mL | 0.8039 mL | 2.0098 mL | |
| 20 mM | 0.0603 mL | 0.3015 mL | 0.6029 mL | 1.5074 mL | |
| 25 mM | 0.0482 mL | 0.2412 mL | 0.4824 mL | 1.2059 mL | |
| 30 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0049 mL | |
| 40 mM | 0.0301 mL | 0.1507 mL | 0.3015 mL | 0.7537 mL | |
| 50 mM | 0.0241 mL | 0.1206 mL | 0.2412 mL | 0.6029 mL | |
| 60 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5025 mL | |
| 80 mM | 0.0151 mL | 0.0754 mL | 0.1507 mL | 0.3768 mL | |
| 100 mM | 0.0121 mL | 0.0603 mL | 0.1206 mL | 0.3015 mL |
(R,R)-S63845 Related Classifications
HY-100741C Related Classifications
Powered by Bioz