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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
toxin molecule
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "toxin molecule" in MCE Product Catalog:
Cat. No.: HY-187075
CAS No.: 2878440-81-2
Target:
Research Areas:
2-MSP-VA-PAB-MMAE (Compound B-2) is a conjugate of the toxin molecule MMAE (HY-15162) and a linker, which can be used to construct antibody-drug conjugates (ADCs) .
Cat. No.: HY-185492
CAS No.: 1799659-90-7
Research Areas:
MC-cBu-Cit-seco-CBI dimer (Compound 10) is a conjugate of an ADC drug toxin molecule and a linker, which consists of a DNA alkylating agent connected to a reactive maleimide via a protease-cleavable peptidomimetic linker .
Cat. No.: HY-184561
CAS No.: 3128805-51-3
Target:
Research Areas:
L05-EXd is a toxin-linker conjugate, in which the toxin component is Exatecan (HY-13631). L05-EXd can be conjugated with Polatuzumab (HY-P99042) to form the ADC molecule Polatuzumab-L05-EXd. L05-EXd is applicable to research related to small cell lung cancer and non-small cell lung cancer .
Cat. No.: HY-P7521A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ANTXR1; FLJ10601; ANTXR Cell Adhesion molecule 1; Tumor Endothelial Marker 8 Precursor; Anthrax toxin Receptor 1; Anthrax toxin Receptor; TEM8; ANTXR1 Protein; ATR; 2310008J16Rik; Tumor Endothelial Marker 8; 2810405N18Rik; FLJ21776; GAPO
Species:
Human
Source:
HEK293
Cat. No.: HY-P77226
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ANTXR1; FLJ10601; ANTXR Cell Adhesion molecule 1; Tumor Endothelial Marker 8 Precursor; Anthrax toxin Receptor 1; Anthrax toxin Receptor; TEM8; ANTXR1 Protein; ATR; 2310008J16Rik; Tumor Endothelial Marker 8; 2810405N18Rik; FLJ21776; GAPO
Species:
Human
Source:
HEK293
Cat. No.: HY-183558
CAS No.: 3107874-31-4
Research Areas:
AV-DL055 is a conjugate of the toxin molecule Exatecan (HY-13631) and the linker AV-L03 (HY-183678). AV-DL055 can be used to construct ADCs, such as T-DL055 .
Cat. No.: HY-185765
Research Areas:
MC-PEG4-β-Glu-Baloxavir is a conjugate of a toxin molecule and a linker, with Baloxavir (HY-109025A) as the payload. Baloxavir is an effective and selective inhibitor of cap-dependent nucleases (CEN). Baloxavir inhibits the transcription and replication of viral RNA and has strong antiviral activity.
Cat. No.: HY-P705240
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ANTXR1; FLJ10601; ANTXR Cell Adhesion molecule 1; Tumor Endothelial Marker 8 Precursor; Anthrax toxin Receptor 1; Anthrax toxin Receptor; TEM8; ANTXR1 Protein; ATR; 2310008J16Rik; Tumor Endothelial Marker 8; 2810405N18Rik; FLJ21776; GAPO
Species:
Human
Source:
HEK293
Cat. No.: HY-182972
CAS No.: 3110422-32-4
Target:
Research Areas:
Mal-PEG4-NPV-PABC-DMEDA-tofacitinib is a conjugate of a toxin and a linker, consisting of the JAK inhibitor Tofacitinib (HY-40354) and the linker Mal-PEG4-NPV-PABC-DMEDA (HY-182977). Mal-PEG4-NPV-PABC-DMEDA-tofacitinib can be used for the synthesis of ADC molecules .
Cat. No.: HY-184739
CAS No.: 3120799-14-3
Target:
Research Areas:
SMP-70067-L (DL10) is a conjugate of a toxic molecule and a linker, in which the toxin moiety is Exatecan (HY-13631) and the linker moiety is SMP-93566-4-Leu-Cit-PAB-Glu (Ac) (HY-184740). SMP-70067-L can be used to synthesize the ADC SMP-70067-X .
Cat. No.: HY-123395
CAS No.: 908813-78-5
Target:
Research Areas:
NSC-84096 is an endopeptidase activity inhibitor with the ability to inhibit the activity of botulinum neurotoxin type A light chain (rBoNT/A-LC). NSC-84096 is able to effectively inhibit the enzymatic activity of botulinum neurotoxin in vitro, indicating its potential in inhibiting botulism. The mechanism of action of NSC-84096 may provide hope for the development of small molecule compounds targeting these deadly toxins .
Cat. No.: HY-188059
CAS No.: 3058592-88-1
Synonyms: ZL-1310
Research Areas:
Zocilurtatug pelitecan (ZL-1310) is a blood-brain barrier-penetrating antibody-drug conjugate targeting DLL3. It consists of the antibody component Zocilurtatug (HY-P992148) and the toxin-linker molecule DL-01 (HY-155870). Zocilurtatug pelitecan induces cell cycle arrest and apoptosis in tumor cells, and inhibits the growth of established human tumors in xenograft models. It can be used in research on extensive-stage small cell lung cancer (SCLC) and neuroendocrine tumors .
Cat. No.: HY-184522
Research Areas:
TPA (bi (Tos))-γ-Glu (PEG23)-Gly-Gly-Gly-C2-NH-PNU-159682 (Fig.4 B) is a conjugate of a toxin molecule and a linker, which can be used to synthesize ADCs. TPA (bi (Tos))-γ-Glu (PEG23)-Gly-Gly-Gly-C2-NH-PNU-159682 consists of the DNA alkylating/inserting agent PNU-159682 (HY-16700) and the linker (HY-184523) .
Cat. No.: HY-178898
CAS No.: 13072-74-7
Cat. No.: HY-L220
91 compounds
Biotoxins, also referred to as natural toxins, are chemical substances produced by plants, animals, or microorganisms that exert toxic effects on other living organisms. Due to unique biological activities, biotoxins have been widely applied in molecular biology, physiology, pharmacology, and the clinical diagnosis and treatment of various human diseases, becoming an important source of natural drug development. Biotoxins can specifically bind to and interfere with intracellular signaling molecules or receptors, thereby altering cellular signaling processes. Leveraging this characteristic, biotoxins can be used to study the regulatory mechanisms of cellular signaling pathways. For example, neurotoxins such as snake venom peptides can be used to investigate the functional regulation of neurotransmitter receptors and ion channels. Additionally, biotoxins have demonstrated significant potential in drug development across various fields, including neurological diseases, cardiovascular diseases, anticoagulation, and anti-cancer therapies. With advancements in high throughput screening, structural optimization, and antibody-toxin conjugation technologies, numerous biotoxins or their structural analogs have been successfully brought to market, such as Ziconotide, Captopril, Bivalirudin, and Eptifibatide.
MCE offers 91 types of biotoxins, including neurotoxins, cardiotoxins, mycotoxins, and more.
Cat. No.: HY-P992488
Synonyms: ZV0501 Antibody
Research Areas:
ZV05 (ZV0501 Antibody) is an anti-5T4 monoclonal antibody with an EC50 of 4.3 ng/mL against h5T4. ZV05 does not induce apoptosis or interfere with cell cycle progression. ZV05 accumulates specifically in 5T4-positive tumor xenografts. ZV05 can serve as the antibody component of antibody-active molecule conjugates (ADCs) to bind the 5T4 glycoprotein, thereby enabling targeted delivery of toxins. ZV05 is used in studies of 5T4-positive cancers, including triple-negative breast cancer .
Cat. No.: HY-185816
Research Areas:
TQB2102 is a bispecific epitope antibody-drug conjugate targeting HER2, composed of the antibody Rolditamig (HY-P992130) and the toxin molecule Deruxtecan-d2 (HY-13631ES3). TQB2102 binds to the ECD2 and ECD4 domains of HER2, promotes its own internalization by HER2-expressing cells, and delivers deuterated DXd payload to inhibit topoisomerase I. TQB2102 induces antibody-dependent cellular cytotoxicity, DNA damage, bystander killing activity, and inhibits cancer cell proliferation. TQB2102 can be used in research related to various cancers including metastatic breast cancer, colorectal cancer, and gastric/gastroesophageal junction adenocarcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
