Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
87 Results for "
cellular systems
" in MedChemExpress (MCE) Product Catalog:
Products (87)
87 Results for "cellular systems" in MCE Product Catalog:
Cat. No.: HY-P991812
Target:
Research Areas:
Cat. No.: HY-183042
CAS No.: 630106-85-3
p38α-IN-12 is an orally bioavailable p38α MAPK inhibitor, with an IC50 of 0.11 nM and a Ki of 0.2 nM against human targets. p38α-IN-12 inhibits the production of TNFα in cellular systems and exerts in vivo efficacy in acute mouse models .
Cat. No.: HY-186106
CAS No.: 2247437-94-9
3-Deoxyanguibactin is a siderophore and Fe(III) chelator/iron delivery agent. 3-Deoxyanguibactin binds Fe(III) with 2:1 stoichiometry in liquid phase, delivers iron into Acinetobacter baumannii cells, and relies on the BauA outer membrane receptor and bau transport system for cellular entry. 3-Deoxyanguibactin can be used for the research of acinetobacter baumannii infection .
Cat. No.: HY-N17732
CAS No.: 109469-87-6
Category:
Target:
Cat. No.: HY-K6141
MCE Human Brain Organoid (Expansion) Kit contains Human Brain Organoid Expansion Basal Medium and Human Brain Organoid Expansion Culture Supplements. This kit enables the efficient in vitro generation of human forebrain organoids (hFBs). Within this culture system, human brain tissue can spontaneously form organoid structures that faithfully recapitulate key features of in vivo cellular heterogeneity and complex tissue organization.
Cat. No.: HY-139200A
CAS No.: 2101981-60-4
(R)-DOTMA is a cationic lipid that can be used to construct lipid nanoparticles and lipoplexes. (R)-DOTMA binds nucleic acid molecules such as mRNA through electrostatic interactions, facilitating nucleic acid encapsulation and cellular delivery. (R)-DOTMA can form lipid systems with DOPE (HY-112005) or cholesterol (HY-N0322). (R)-DOTMA is applicable to mRNA delivery, vaccine development, cancer immunotherapy and gene editing research .
Cat. No.: HY-157293
CAS No.: 1374040-22-8
Research Areas:
PBI4600 is a quinone-trimethyl-locked coelenterazine-based proluminescent substrate and a probe for detecting the redox status and viability of metabolically active cells. PBI4600 releases the coelenterazine reporter group upon reduction by metabolically active cells, generating a luminescent signal through the bioluminescence system, with signal intensity correlating with cellular redox status and metabolic activity. PBI4600 can be used for research related to the redox status and viability of living cells .
Cat. No.: HY-K6143
MCE Mouse Fetal Brain Organoid (Expansion) Kit contains Mouse Fetal Brain Organoid Expansion Basal Medium and Mouse Fetal Brain Organoid Expansion Culture Supplement . This kit enables the efficient in vitro generation of mouse fetal brain organoids (mFBs). Within this culture system, mouse fetal brain tissue can spontaneously form organoid structures that faithfully recapitulate key features of in vivo cellular heterogeneity and complex tissue organization.
Category:
Cat. No.: HY-114118F5
Synonyms: Semaglutide-Cys(Cy5)
Target:
GLP Receptor Insulin Receptor α-synuclein Apoptosis p38 MAPK Autophagy Fluorescent Dye Bcl-2 Family
Research Areas:
Cat. No.: HY-D3121
CAS No.: 2763752-95-8
Target:
Research Areas:
HOTPy is a mitochondria-targeted fluorescent viscosity probe with aggregation-induced emission properties, which responds to microenvironmental viscosity. HOTPy can recognize the abnormal increase in mitochondrial viscosity and capture dynamic viscosity changes in acute alcoholic liver injury models at both cellular and in vivo levels. The maximum absorption peak of HOTPy in PBS solution is at 379 nm; its maximum emission peak reaches 611 nm in a high-viscosity glycerol system. HOTPy can be used for the research of acute alcoholic liver injury .
Cat. No.: HY-182307
CAS No.: 1018153-87-1
Target:
Research Areas:
OH14 is a cellular FLICE-like inhibitory protein (cFLIP) inhibitor and TNF-related apoptosis-inducing ligand (TRAIL) sensitizer. OH14 selectively binds to the DED1 pocket of cFLIP, disrupting its recruitment to the TRAIL-death inducing signalling complex without affecting procaspase-8 recruitment to FADD, allowing procaspase-8 activation. OH14 promotes TRAIL-mediated apoptosis and impairs cell viability in breast cancer systems when combined with TRAIL. OH14 can be used for the research of breast cancer .
Cat. No.: HY-164579
CAS No.: 1364335-16-9
NH2-GG-DSPE is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.
Cat. No.: HY-189222
CAS No.: 3118096-98-0
Target:
Research Areas:
RP04340 is an orally active, selective pan-KRAS PROTAC degrader. RP04340 hijacks the CRBN E3 ligase and the cellular proteasome system to degrade KRAS, without degrading HRAS, NRAS, or common CRBN neosubstrates. RP04340 inhibits KRAS downstream signaling pathways, including pERK and DUSP6. RP04340 exhibits anticancer activity in various KRAS-mutant cancers. RP04340 can be used to study kras-driven cancers, including pancreatic ductal adenocarcinoma, colorectal cancer, and lung adenocarcinoma .
Cat. No.: HY-N17326
CAS No.: 242794-72-5
Cat. No.: HY-157678
CAS No.: 321883-39-0
Synonyms: 18:2 PS sodium
1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine sodium (18:2 PS sodium) is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.
Cat. No.: HY-L011
2,278 compounds
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.
MCE designs a unique collection of 2,278 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.
Cat. No.: HY-181134
CAS No.: 2715104-46-2
PROTAC HMGCR Degrader-2 is a HMGCR PROTAC degrader with an IC50 value of 0.25 μM. PROTAC degrades HMGCR-2 in Insig-silenced HepG2 cells with a DC50 of 0.12 μM. PROTAC HMGCR Degrader-2 takes PROTAC HMGCR Degrader-1 (HY-171823) as the oral prodrug. PROTAC HMGCR Degrader-2 degrades HMGCR by the VHL-dependent ubiquitin-proteasome system and reduces cellular cholesterol in HepG2 cells. PROTAC CDK2/4/6 Degrader-2 can be used for hyperlipidemia research .
Cat. No.: HY-187219
Research Areas:
CX-Se13 is an orally active pulmonary fibrosis inhibitor with anti-inflammatory and antioxidant activities. CX-Se13 regulates the Keap1/Nrf2/HO-1/NQO1, YAP/TAZ-TEAD, NF-κB p65 and TGF-β/Smads signaling pathways. CX-Se13 activates the cellular antioxidant defense system, restores redox balance, alleviates inflammatory responses, reduces collagen deposition, decreases pro-inflammatory cytokine levels and inhibits pathological progression. CX-Se13 can be used in studies related to pulmonary fibrosis .
Cat. No.: HY-125863D
Synonyms: G6PD, Torula yeast
Target:
Research Areas:
Glucose-6-phosphate dehydrogenase, Torula yeast (G6PD, Torula yeast) (EC 1.1.1.49) is an NADP-dependent antioxidant metabolic enzyme. Glucose-6-phosphate dehydrogenase, Torula yeast can be induced by sublethal doses of Menadione (HY-B0332) and increasing concentrations of NaCl. Glucose-6-phosphate dehydrogenase, Torula yeast catalyzes the oxidation of glucose-6-phosphate (G6P) to 6-phosphoglucono-δ-lactone, while reducing NADP + to NADPH, providing reducing power for the antioxidant defense system and cellular redox balance of bacteria. Glucose-6-phosphate dehydrogenase, Torula yeast is used in research related to diabetic complications .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
