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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
948 Results for "
sensitive
" in MedChemExpress (MCE) Product Catalog:
Products (948)
948 Results for "sensitive" in MCE Product Catalog:
Art. -Nr.: HY-DY1026
Solvent and concentration: DMSO: 1 mM
Art. -Nr.: HY-N20619
CAS. Nr.: 475673-78-0
Target:
Art. -Nr.: HY-P1117A
Forschungsgebiete:
Art. -Nr.: HY-W040144
CAS. Nr.: 76-60-8
Art. -Nr.: HY-W040430
CAS. Nr.: 494-97-3
Target:
Art. -Nr.: HY-W040430A
CAS. Nr.: 101832-65-9
Category:
Alkaloids Pyrrole Alkaloids Other Diseases Pyridine Alkaloids Endogenous metabolite Disease Research Fields
Target:
Art. -Nr.: HY-W923198
CAS. Nr.: 480439-15-4
Synonyms: Methacryloyloxy fluorescein
Art. -Nr.: HY-P703239
Synonyms: CUL5; CUL-5; Cullin 5; VACM1; VACM-1; Cullin-5 (Vasopressin-Activated Calcium-Mobilizing Receptor-1); Cullin-5; Vasopressin-Activated Calcium-Mobilizing Receptor-1; Vasopressin-Activated Calcium-Mobilizing Receptor 1; RNF7; sensitive To Apoptosis Zinc RIN
Species:
Human
Source:
Sf9 insect cells
Art. -Nr.: HY-P703351
Reinheit: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SLC5A7; Solute Carrier Family 5 (Choline Transporter), Member 7; Solute Carrier Family 5 Member 7; Motor Neuronopathy, Distal Hereditary, Type VIIA; CHT1; Hemicholinium-3-sensitive Choline Transporter; High Affinity Choline Transporter 1; SLC5A7 Protein;
Species:
Human
Source:
HEK293
Art. -Nr.: HY-101360R
CAS. Nr.: 10045-45-1
Synonyms: 1-Ethyl-2-benzimidazolinone (Standard)
Target:
Forschungsgebiete:
1-EBIO (1-Ethyl-2-benzimidazolinone) (Standard) is the analytical standard of 1-EBIO (HY-101360). This product is intended for research and analytical applications. 1-EBIO is an activator of Ca 2+ sensitive K + channels wirh an EC50 of 136 μM for KCa3.1. 1-EBIO induces Cl - secretion, K + conductance, membrane hyperpolarization, and afterhyperpolarisation currents. 1-EBIO reduces epileptiform activity, seizure incidence, and rescues cells from Ionomycin (HY-13434)-induced death .
Art. -Nr.: HY-105521A
CAS. Nr.: 94096-42-1
Synonyms: (S)-Nafenodone; LU-43706
Target:
Forschungsgebiete:
Dexnafenodone hydrochloride ((S)-Nafenodone; LU-43706) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone hydrochloride inhibits the fast inward Na + current and slow inward Ca 2+ current in cardiomyocytes. Dexnafenodone hydrochloride inhibits voltage-gated and receptor-activated Ca 2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca 2+ stores, suppresses agonist-stimulated Ca 2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone hydrochloride can be used in the research of depression .
Target:
Forschungsgebiete:
Menaquinone 9 is a naphthoquinone-type vitamin K and electron transport component produced by bacteria. Menaquinone 9 is an orally active analog of Vitamin K2 (HY-109569). Menaquinone 9 acts as an ultraviolet-sensitive, photooxidizable substrate that generates more polar photodegradation products under oxygen and ultraviolet irradiation. Menaquinone 9 binds to the αβ dimer of Escherichia coli nitrate reductase, supporting electron transport within the αβ subunit structure of the enzyme. Menaquinone 9 serves as a precursor for bone Menaquinone-4 (HY-B2156). Menaquinone 9 can be used in studies related to metabolic diseases .
Art. -Nr.: HY-160113E
Art. -Nr.: HY-164236
CAS. Nr.: 119242-44-3
Target:
Forschungsgebiete:
C22 Glucosylceramide (d18:1/22:0) is a bioactive sphingolipid composed of a d18:1 sphingoid base and a 22:0 fatty acid chain. C22 Glucosylceramide (d18:1/22:0) specifically exists in Doxorubicin (HY-15142A)-sensitive cancer cells, and its circulating concentration is positively correlated with the incidence of cardiovascular events. C22 Glucosylceramide (d18:1/22:0) has been widely used in research related to cardiovascular diseases, hypercholesterolemia, metabolic syndrome, breast adenocarcinoma and other fields .
Art. -Nr.: HY-174343
CAS. Nr.: 1228283-36-0
ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (QO)-site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research .
Art. -Nr.: HY-19927A
CAS. Nr.: 1645260-76-9
Target:
Forschungsgebiete:
DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome .
Target:
Forschungsgebiete:
Acetohexamide (Standard) is the analytical standard of Acetohexamide. This product is intended for research and analytical applications. Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .
Art. -Nr.: HY-D3100
CAS. Nr.: 2412201-40-0
Target:
Forschungsgebiete:
NRTP is a fluorescent probe used for mitochondrial polarity detection and photothermal sensitization. NRTP targets mitochondria via a positively charged triphenylphosphonium moiety, which is attracted by the negative mitochondrial membrane potential; meanwhile, its polarity-sensitive Nile red fluorophore enables it to perceive changes in environmental polarity. NRTP reduces cell viability when used as a photothermal sensitizer. The excitation wavelength is 561 nm, and emission light is collected in two channels: 570-620 nm (red channel) and 665-735 nm (deep red channel). NRTP can reveal the downregulation of mitochondrial polarity during light-induced cell death, as well as polarity changes triggered by exposure to cholesterol .
Art. -Nr.: HY-D3111
CAS. Nr.: 1240465-12-6
Target:
Forschungsgebiete:
DBHA is a long-wavelength polarity-sensitive fluorescent probe based on Nile Red. Under the catalysis of Pd (OAc)2/TPPTS, DBHA site-selectively labels protein tyrosine residues via a π-allyl palladium complex intermediate. Utilizing the property that its maximum emission wavelength blue-shifts with decreasing local polarity (650 nm in aqueous solution → 584-608 nm in hydrophobic domains), it detects changes in local polarity and conformation of protein tyrosine domains under acid/thermal denaturation conditions. DBHA can be used in studies related to SOD1-associated oxidative stress neurodegenerative diseases .
Art. -Nr.: HY-P3269
CAS. Nr.: 178805-91-9
Target:
Forschungsgebiete:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
