Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
947 Results for "
Cysteine
" in MedChemExpress (MCE) Product Catalog:
Products (947)
947 Results for "Cysteine" in MCE Product Catalog:
Cat. No.: HY-120914
CAS No.: 170950-29-5
Synonyms: GO-Y015
Target:
Glutathione Peroxidase Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism Drug Derivative TrxR
Research Areas:
TrxR1-IN-B19 (GO-Y015) is a Curcumin (HY-N0005) derivative and TrxR1 inhibitor. TrxR1-IN-B19 inhibits de novo selenoprotein synthesis, suppresses SeP and GPx expression, and impairs selenium incorporation into Sec-tRNA[Sec]. TrxR1-IN-B19 induces Nrf2 accumulation through Keap1 cysteine modification, HO-1 expression, GSH synthesis, ROS accumulation, ER stress, mitochondrial dysfunction, Apoptosis, and G2/M phase arrest. TrxR1-IN-B19 improves glucose tolerance and insulin sensitivity, lowers blood glucose, inhibits tumor growth, and reduces arsenic accumulation. TrxR1-IN-B19 can be used for research on type 2 diabetes, arsenite-induced toxicity, and gastric cancer .
Cat. No.: HY-137839
CAS No.: 927827-98-3
Target:
Research Areas:
Anti-inflammatory agent 121 is a protease inhibitor, with IC50 values against different targets as follows: 1.3 μM (Staphylococcus aureus type I staphylokinase), 2.2 μM (Staphylococcus aureus type II staphylokinase), 2.3 μM (human MMP-1), 2.7 μM (human MMP-2), 1.4 μM (human MMP-8), 4.6 μM (human MMP-9), and 79 μM (human ADAM17). Anti-inflammatory agent 121 inhibits the activities of staphylococcal serine protease glutamyl endopeptidase (V8 protease) and cysteine protease staphylococcal protease B in Staphylococcus aureus cultures. Anti-inflammatory agent 121 inhibits protease activity in skin wash samples, metalloprotease (staphylokinase) activity in Staphylococcus aureus culture supernatants, and staphylokinase-mediated activation of pro-urokinase-type plasminogen activator (pro-uPA). Anti-inflammatory agent 121 can be used in the research of atopic dermatitis .
Cat. No.: HY-179612
Target:
Research Areas:
SARS-CoV-2 3CLpro-IN-34 (Compound 55) is a highly efficient non-covalent inhibitor of the SARS-CoV-2 3CL pro protease (b. SARS-CoV-2 3CL pro protease) with an IC50 of 1.9 μM. SARS-CoV-2 3CLpro-IN-34 can inhibit the 3CL pro protein of SARS-CoV-1, with its IC50 being 3.2 μM, and it shows high selectivity towards host cysteine proteases (such as cathepsins L/K and calpain). SARS-CoV-2 3CLpro-IN-34 exhibits antiviral activity in cells infected with SARS-CoV-2, with its EC50 being 25 μM, and it is not affected by P-gp inhibitors and shows no significant cytotoxicity. SARS-CoV-2 3CLpro-IN-34 can be used for research on SARS-CoV-2 infection .
Cat. No.: HY-P71293
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPIND1; Serine (Or Cysteine) Proteinase Inhibitor, Clade D (Heparin Cofactor), Member 1; Prev. HCF2; Heparin Cofactor II; HLS2; Serpin D1; Serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1; Leuserpin 2; Heparin Cofactor 2; THPH10; D22S673
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P71306
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINB9; Testicular Tissue Protein Li 180; Prev. PI9; Serpin B9; CAP3; CAP-3; Cytoplasmic Antiproteinase 3; PI-9; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 9; Serpin Peptidase Inhibitor, Clade B, Member 9; Serpin Peptidase In
Species:
Human
Source:
HEK293
Cat. No.: HY-P71708
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CASP8; Apoptotic Cysteine Protease; Caspase 8; Apoptotic Protease Mch-5; FLICE; FADD-Like ICE; MCH5; CAP4; MACH; FADD-Homologous ICE/CED-3-Like Protease; Caspase-8; FADD-Homologous ICE/Ced-3-Like Protease; Casp-8; MACH-Beta-1/2/3/4 Protein; Caspase 8, Apo
Species:
Human
Source:
E. coli
Cat. No.: HY-P76641
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SERPINB8; Peptidase Inhibitor 8; Prev. PI8; PI-8; CAP2; Protease Inhibitor 8 (Ovalbumin Type); Cytoplasmic Antiproteinase 2; C18orf53; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 8; CAP-2; Serpin Peptidase Inhibitor, Clade B (Ov
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P77199
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPIND1; Serine (Or Cysteine) Proteinase Inhibitor, Clade D (Heparin Cofactor), Member 1; Prev. HCF2; Heparin Cofactor II; HLS2; Serpin D1; Serpin Peptidase Inhibitor, Clade D (Heparin Cofactor), Member 1; Leuserpin 2; Heparin Cofactor 2; THPH10; D22S673
Species:
Human
Source:
HEK293
Cat. No.: HY-P7385A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINB5; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5; Prev. PI5; Peptidase Inhibitor 5; Maspin; Serpin B5; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 5; PI-5; Serpin Family B Member 5; Protease Inhibitor 5 (Maspi
Species:
Human
Source:
E. coli
Cat. No.: HY-L081
185 compounds
Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.
Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.
MCE supplies a unique collection of 185 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.
Cat. No.: HY-141439
CAS No.: 936475-62-6
Research Areas:
TBE 31 is an orally active Keap1/Nrf2 pathway activator and NQO1 inducer with a Dm value of 1.1 nM for NQO1. TBE 31 binds to cysteine residues of Keap1, inhibits ubiquitination and degradation of Nrf2, thereby activating the expression of ARE-dependent genes. TBE 31 induces cytoprotective enzymes including NQO1 and GST isoforms, promotes Nrf2 accumulation, and upregulates Nrf2-regulated genes related to antioxidation and lipid metabolism. TBE 31 inhibits pro-inflammatory responses, formation of AFB1-DNA adducts, endoplasmic reticulum stress, cell apoptosis (apoptosis), hepatic fibrosis, oxidative stress, and the expression of ChREBP. TBE 31 reduces the number of tumors in a mouse model of ultraviolet-induced skin carcinogenesis. TBE 31 enhances nerve growth factor-induced neurite outgrowth. TBE 31 attenuates LPS-induced serum TNF-α levels and immobility time in mice. TBE 31 can be used in research related to liver cancer, skin cancer, inflammation-related depression, and non-alcoholic steatohepatitis .
Cat. No.: HY-N9932
CAS No.: 125519-47-3
Cat. No.: HY-W594061
CAS No.: 1811541-14-6
Target:
Research Areas:
JF635-HTL is a Fluorescent dye for spatiotemporally controlled live cell imaging and single-molecule localization microscopy SMLM. Its detection mechanism depends on the conformational change of a photoswitchable HaloTag psHaloTag, which integrates the light-responsive AsLOV2 domain: in the dark state, the folded Jα helix of AsLOV2 maintains the dye in a predominantly closed, non-fluorescent form; upon 450 nm illumination, a metastable photo-adduct forms between a cysteine side chain and the FMN cofactor of AsLOV2, causing undocking and unfolding of the Jα helix, which propagates a conformational change to the HaloTag near the dye binding site, shifting the dye's equilibrium to the open, fluorescent form; this process is fully reversible in the dark as the Jα helix refolds spontaneously, returning the dye to the closed, non-fluorescent state. For psHaloTag1a labeled with JF635-HTL, the excitation/emission wavelengths for the ON state are Ex/Em = 642/655 nm, while for psHaloTag1b labeled with JF635-HTL, the wavelengths are Ex/Em = 639/655 nm; when bound to wild-type HaloTag, the wavelengths are Ex/Em = 640/656 nm .
Cat. No.: HY-L908
1,244 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.
MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.
Cat. No.: HY-P87373
Synonyms: Serine (or Cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 antibody; Serpin A7 antibody; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 antibody; Serpin peptidase inhibitor; clade A; member 7 antibody; Serpina7 antibody; T4 binding globulin antibody; TBG antibody; TBG
Cat. No.: HY-P87373A
Synonyms: Serine (or Cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 antibody; Serpin A7 antibody; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 antibody; Serpin peptidase inhibitor; clade A; member 7 antibody; Serpina7 antibody; T4 binding globulin antibody; TBG antibody; TBG
Cat. No.: HY-P81161
Synonyms: Apoptotic Cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; CAP4; Caspase 8 precursor; CCAAT Enhancer Binding Protein alpha; CEBP; CEBP A; CEBP alpha; CEBPA; FADD homologous ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH; MCH5; MORT1 associated CED 3 homolog; CEBP α, CEBP-α.
Cat. No.: HY-P811964
Synonyms: SERPINB8; Serpin Family B Member 8; CAP2; Cytoplasmic Antiproteinase 2; PI8; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 8; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8; Peptidase Inhibitor 8; Serpin B8; PI-8; Protease Inhibitor 8 (Ovalbumin Type); C18orf53; CAP-2; PSS5
Cat. No.: HY-P811964A
Synonyms: SERPINB8; Serpin Family B Member 8; CAP2; Cytoplasmic Antiproteinase 2; PI8; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 8; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 8; Peptidase Inhibitor 8; Serpin B8; PI-8; Protease Inhibitor 8 (Ovalbumin Type); C18orf53; CAP-2; PSS5
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
