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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
651 Results for "
73
" in MedChemExpress (MCE) Product Catalog:
Products (651)
651 Results for "73" in MCE Product Catalog:
1
1 Cited Publications
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GSK8814 is a potent and selective ATAD2 bromodomain chemical probe and inhibitor (IC50 = 0.059 μM), with a binding constant pKd = 8.1 and a pKi = 8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 can be researched for cancer associated with ATAD2 bromodomain .
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1 Cited Publications
Synonyms: XEN1101; Encukalner
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Azetukalner (XEN1101) is a selective and orally active Kv7.2/Kv7.3 potassium channel opener with an EC50 of 27 nM. Azetukalner is approximately 4-fold more selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50 of 94 nM) and Kv7.4 (EC50 of 113 nM) channels. Azetukalner exhibits a selectivity >100-fold for Kv7 channels over other ion channels and receptors. Azetukalner can be used for the study of focal epilepsy .
1
1 Cited Publications
Cat. No.: HY-N2376
CAS No.: 35775-49-6
Category:
Flavones Plants Bignoniaceae Extract Oroxylum indicum (Linn.) Bentham ex Kurz Flavonoids Monophenols Other Diseases Phenols Disease Research Fields Medicago truncatula Gaertn. Labiatae Extract
Target:
1
1 Cited Publications
Cat. No.: HY-P7188
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL1; Neutrophil-Activating Protein 3; Prev. GRO1; Fibroblast Secretory Protein; Prev. MGSA; C-X-C Motif Chemokine 1; Prev. FSP; GRO-Alpha(1-73); SCYB1; GRO1 Oncogene (Melanoma Growth-Stimulating Activity); NAP-3; Melanoma Growth Stimulatory Activity Alp
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73915
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HSPA8; Epididymis Secretory Sperm Binding Protein Li 72p; Prev. HSPA10; Constitutive Heat Shock Protein 70; HSC70; Epididymis Luminal Protein 33; HSP73; Heat Shock Cognate Protein 54; Heat Shock Cognate 71 KDa Protein; Heat Shock 70kd Protein 10; HSC71; Heat Shock 70kD Protein 8; Lipopolysaccharide-Associated Protein 1; HSPA8 Protein; Heat Shock Protein Family A Member 8; CDNA FLJ77848; Heat Shock 70 KDa Protein 8; HEL-S-72p; Heat Shock 70kDa Protein 8; HSC54; LPS-Associated Protein 1; HSP71; HEL-33; NIP71; LAP-1; LAP1; Heat Shock Protein Family A (Hsp70) Member 8; N-Myristoyltransferase Inhibitor Protein 71
Species:
Human
Source:
E. coli
Cat. No.: HY-P990245
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BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure .
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CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology .
Cat. No.: HY-P990263
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5′-Nucleotidase, Microorganism (CD73) is an intrinsic membrane glycoprotein present as an ectoenzyme. 5′-Nucleotidase catalyzes hydrolysis of 5-nucleotides to their corresponding nucleosides .
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GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus .
Cat. No.: HY-DP5354AF
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(S)-BAY 73-6691 is the isomer of BAY 73-6691 (HY-104028), and can be used as an experimental control. BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor .
Cat. No.: HY-P5457
CAS No.: 500719-13-1
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Cat. No.: HY-161688
CAS No.: 2323571-16-8
HDAC-IN-73 (compound P-503) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-73 shows IC50s values of 0.17, 0.49 µM for HDAC1 and HDAC6, respectively. Notably, HDAC-IN-73's inhibitory potency against HDAC6 is heightened, exhibiting a 9-fold greater efficacy than PsA (HY-N2150) (IC50=3.9 μM). HDAC-IN-73 shows potent antiproliferative activity, induces apoptosis, and causes cell cycle arrest at G2 / M phase. HDAC-IN-73 has the potential to be used for the research of cancer such as colon cancer .
Cat. No.: HY-147590
CAS No.: 2766565-88-0
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CD73-IN-9 (compound 2) is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-9 can be used for the study of tumor-related diseases .
Cat. No.: HY-172527
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CD73-IN-20 (Compound 5c) is an e5′NT (CD73) inhibitor (IC50: 0.37 μM). CD73-IN-20 also inhibits other ectonucleotidases, with IC50s of 1.12 μM (h-ENPP1), 1.37 μM (h-ENPP3), 1.66 μM (r-e5′NT), 1.48 μM (h-TNAP), respectively. CD73-IN-20 can be used for cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
