2184 Results for "

Fc

" in MedChemExpress (MCE) Product Catalog:
Products (2184)

2184 Results for "Fc" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P72603
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Ig gamma-2A chain C region; Immunoglobulin heavy chain gamma polypeptide; Ighg
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P77874
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: APLN; APEL; Apelin; Apelin, AGTRL1 Ligand; XNPEP2; AGTRL1 Ligand; APJ Endogenous Ligand
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P73397
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: 2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD
Species:  
Virus
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P7860
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: F10; Prothrombinase; Coagulation Factor X; Factor Xa; Stuart-Prower Factor; Factor X; Stuart Factor; FXA; FX
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P99014
CAS No.: 1864871-20-4
Synonyms: ARGX-110

Research Areas:  

Inflammation/Immunology Cancer

Cusatuzumab (ARGX-110) is a selective competitive blocker targeting CD70 (with an equilibrium dissociation constant of 17 pM for binding to human CD70). Cusatuzumab also possesses enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. It is a humanized IgG1 monoclonal antibody, artificially synthesized through humanization and genetic engineering modifications (CH2 region mutation to enhance effector function). Cusatuzumab has a dual mechanism of action: firstly, it competitively blocks the interaction between CD70 and CD27, inhibiting the CD27-NF-κB signaling pathway, reducing regulatory T cell (Treg) activation and tumor cell proliferation; secondly, by enhancing binding to FcγRIIIa, it mediates ADCC and antibody-dependent cellular phagocytosis (ADCP), directly lysing CD70-positive tumor cells. Cusatuzumab can efficiently eliminate leukemia stem cells (LSCs), induce tumor cell differentiation and apoptosis, restore immune surveillance, and target CD70-positive tumors. Cusatuzumab is used in the study of acute myeloid leukemia (AML) .
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1
1 Cited Publications
Cat. No.: HY-P75444
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD14; Monocyte Differentiation Antigen CD14; CD14 Molecule; CD14 Antigen; Myeloid Cell-Specific Leucine-Rich Glycoprotein; My23 Antigen
Species:  
Mouse
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P70723
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LAG3; Lymphocyte-Activation Gene 3; Lymphocyte Activating 3; CD223 Antigen; CD223; LAG-3; Lymphocyte Activation Gene 3 Protein; FDC
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P72832
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: APOA1; APOA1 Protein; Apolipoprotein A1; Apo(A); Apolipoprotein A-I; HPALP2; Apo-AI; AMYLD3; Epididymis Secretory Sperm Binding Protein; ApoA-I
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P70052
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXADR; CVB3-Binding Protein; CXADR Cell Adhesion Molecule; HCVADR; CAR; HCAR; Coxsackie Virus And Adenovirus Receptor; 46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein; Coxsackievirus And Adenovirus Receptor; CXADR, Ig-Like Cell Adhesion Molecul
Species:  
Mouse
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P70470
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS6; AXSF; Prev. AXLLG; DKFZp666G247; AXL Receptor Tyrosine Kinase Ligand; FLJ34709; Growth Arrest-Specific Protein 6; GAS-6; Growth Arrest Specific 6; AXL Stimulatory Factor
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P71002
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NRCAM; Uncharacterized Protein NRCAM; Neuronal Cell Adhesion Molecule; Ng-CAM-Related; NgCAM-Related Cell Adhesion Molecule; NRCAM Protein; Neuronal Surface Protein Bravo; NEDNMS; KIAA0343; HBravo; Bravo; Nr-CAM; Neuronal Cell Adhesion Molecule Short Isof
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P78324
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LIF; Hepatocyte-Stimulating Factor III; LIF Interleukin 6 Family Cytokine; Differentiation-Inducing Factor; HILDA; Melanoma-Derived LPL Inhibitor; Leukemia Inhibitory Factor; Human Interleukin In DA Cells; CDF; D Factor; DIA; MLPLI; Differentiation Inhibi
Species:  
Mouse
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P70809
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD24; Signal Transducer CD24; CD24 Molecule; Small Cell Lung Carcinoma Cluster 4 Antigen; CD24A; CD24 Antigen; CD24 Antigen (Small Cell Lung Carcinoma Cluster 4 Antigen)
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P7053
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF11B; Osteoprotegerin; Prev. OPG; Tumor Necrosis Factor Receptor Superfamily, Member 11b; OCIF; Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; PDB5; TNF Receptor Superfamily Member 11b; TR1
Species:  
Human
Source:  
CHO
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1
1 Cited Publications
Cat. No.: HY-P70636
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FLT1; Tyrosine-Protein Kinase FRT; Prev. FLT; FLT-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-Derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P70771
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGHG4; Immunoglobulin Heavy Constant Gamma 4; Immunoglobulin Heavy Constant Gamma 4 (G4m Marker); Ig Gamma-4 Chain C Region; Immunoglobulin Heavy Chain Constant Region Gamma 4
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P73073
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CSF3; Filgrastim; Prev. C17orf33; MGC45931; Prev. GCSF; Colony Stimulating Factor 3 Nirs Variant 1; Prev. G-CSF; Granulocyte Colony Stimulating Factor; Granulocyte Colony-Stimulating Factor; Granulocyte-Colony Stimulating Factor; Pluripoietin; Chromosome
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P7831
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD47; Antigen Identified By Monoclonal Antibody 1D8; Prev. MER6; Integrin-Associated Protein; Leukocyte Surface Antigen CD47; Rh-Related Antigen; IAP; CD47 Glycoprotein; Antigenic Surface Determinant Protein OA3; Integrin-Associated Signal Transducer; OA3
Species:  
Rhesus Macaque Cynomolgus
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P70608
Purity:  ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: EGFR; Epidermal Growth Factor Receptor Variant EX12_14del; Prev. ERBB; Cell Proliferation-Inducing Protein 61; ERBB1; Cell Growth Inhibiting Protein 40; ERRP; Receptor Protein-Tyrosine Kinase; Receptor Tyrosine-Protein Kinase ErbB-1; Alternative Protein E
Species:  
Human
Source:  
HEK293
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1 Cited Publications
Cat. No.: HY-P73057
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FGFR4; Receptor Protein-Tyrosine Kinase; Fibroblast Growth Factor Receptor 4; Hydroxyaryl-Protein Kinase; JTK2; Protein-Tyrosine Kinase; TKF; Soluble FGFR4 Variant 1; CD334; Tyrosylprotein Kinase; Tyrosine Kinase Related To Fibroblast Growth Factor Recept
Species:  
Human
Source:  
HEK293
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