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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
156 Results for "
RNA-binding cleft
" in MedChemExpress (MCE) Product Catalog:
Products (156)
156 Results for "RNA-binding cleft" in MCE Product Catalog:
Cat. No.: HY-P810468
Synonyms: Muscleblind Like Splicing Regulator 1, EXP, KIAA0428, MBNL, Triplet-Expansion RNA-binding Protein, Muscleblind-Like Protein 1, EXP42, EXP40, EXP35, Muscleblind-Like Splicing Regulator 1, Muscleblind (Drosophila)-Like, Muscleblind-Like (Drosophila), Muscleblind-Like
Cat. No.: HY-P704522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LIN28A; Zinc Finger CCHC Domain-Containing Protein 1; Prev. LIN28; FLJ12457; ZCCHC1; Lin-28A; CSDD1; Zinc Finger, CCHC Domain Containing 1; Lin-28 Homolog A; Lin-28 Homolog (C. Elegans); LIN-28; RNA-binding Protein LIN-28; Lin-28 RNA binding Posttranscrip
Species:
Human
Source:
E. coli
Cat. No.: HY-P87378
Synonyms: 1810017N16Rik antibody; Chromosome 3p21.1 gene sequence antibody; HUMAGCGB antibody; huOTT3 antibody; One twenty two protein 3 antibody; One-twenty two protein 3 antibody; OTT3 antibody; Putative RNA binding protein 15B antibody; Putative RNA-binding protein 15B antibody; RB15B_HUMAN antibody
Cat. No.: HY-P702591
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PTBP1; PTB4; Prev. PTB; Polypyrimidine Tract binding Protein (Heterogeneous Nuclear Ribonucleoprotein I); Heterogeneous Nuclear Ribonucleoprotein I; 57 KDa RNA-binding Protein PPTB-1; Polypyrimidine Tract-binding Protein 1; HnRNP I; HNRNP-I; Heterogeneous
Species:
Human
Source:
HEK293
Cat. No.: HY-183981
Target:
Research Areas:
RNA binder 4 is an RNA-binding agent that can be used for the synthesis of MJ-NR-27 (HY-183980). MJ-NR-27 is a bifunctional ribonuclease-targeting chimera (RIBOTAC) small molecule that targets NRAS mRNA containing a G-quadruplex structure, and it can be used in cancer research .
Cat. No.: HY-P702630
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FUS; Oncogene TLS; Prev. ALS6; AltFUS; TLS; Fusion (Involved In T(12; 16) In Malignant Liposarcoma); RNA-binding Protein FUS; Fusion, Derived From T(12; 16) Malignant Liposarcoma; HNRNPP2; Fusion Gene In Myxoid Liposarcoma; FUS1; Amyotrophic Lateral Scleros
Species:
Human
Source:
E. coli
Cat. No.: HY-P704622
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: FUS; Oncogene TLS; Prev. ALS6; AltFUS; TLS; Fusion (Involved In T(12; 16) In Malignant Liposarcoma); RNA-binding Protein FUS; Fusion, Derived From T(12; 16) Malignant Liposarcoma; HNRNPP2; Fusion Gene In Myxoid Liposarcoma; FUS1; Amyotrophic Lateral Scleros
Species:
Human
Source:
E. coli
Cat. No.: HY-174590
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.
Cat. No.: HY-P703543
Synonyms: Replicase polyprotein 1ab; ORF1ab polyprotein; rep; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1ab; Endonuclease; Exonuclease; Helicase; Hydrolase; Lyase; Methyltransferase; Nuclease Nucleotidyltransferase; Protease; RNA-binding; RNA-directed RNA polymerase; Thiol protease; Transferase;
Species:
Virus
Source:
Sf9 insect cells
Cat. No.: HY-L917
5,619 compounds
RNA is crucial for the regulation of numerous cellular processes and functions. With the in-depth study of disease mechanisms, processes such as RNA expression, splicing, translation, and stability regulation have become new targets for disease intervention. RNA has provided new therapeutic modalities for metabolic diseases, genetic disorders, and cancer patients, resulting in several innovative drugs.
MCE R&D team collected small molecules targeting RNA from the PDB, R-BIND, ROBIN, and internal database as the positive dataset, and non-targeting RNA small molecules from ROBIN as the negative dataset. Based on the GeminiMol pre-trained model, we encoded the molecules and calculated over 1700 molecular descriptors using Mordred as inputs for the model. Subsequently, we employed 13 deep learning models to learn from the data. All of which yielded good training results, with AUROCs greater than 0.75. Ultimately, we selected the Finetune model to screen HY-L901P, which exhibited the best classification performance, achieving an AUROC of 0.82 and a prediction accuracy of 0.76. We then applied filtering based on StaR rules (with at least two of the following properties: cLogP ≥ 1.5, Molar Refractivity ≥ 4, Relative Polar Surface Area ≤ 0.3) to obtain a library containing approximately 5,000 small molecule compounds targeting RNA. This library serves as a valuable tool for screening small molecules that interact with RNA.
Cat. No.: HY-P75559
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Aconitate hydratase B; EC:4.2.1.3; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; EC:4.2.1.99; Iron-responsive protein-like; IRP-like; RNA-binding protein
Species:
Virus
Source:
E. coli
Cat. No.: HY-P703348
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SUGP1; F23858; Prev. SF4; RNA-binding Protein RBP; Splicing Factor 4; DKFZp434E2216; SURP And G-Patch Domain-Containing Protein 1; CDNA FLJ57089, Highly Similar To Splicing Factor 4; SURP And G-Patch Domain Containing 1; RBP
Species:
Human
Source:
E. coli
Cat. No.: HY-P705480
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FXR1; MYOPMIL; FMR1 Autosomal Homolog 1; MYORIBF; RNA-binding Protein FXR1; CMYO9A; CDNA FLJ58644, Highly Similar To Fragile X Mental Retardation Syndrome-Related Protein 1; CMYO9B; Fragile X Mental Retardation Autosomal Homolog Variant P1K; CMYP9A; Fragi
Species:
Human
Source:
E. coli
Cat. No.: HY-108466R
CAS No.: 37854-59-4
Target:
Research Areas:
Ro 08-2750 (Standard) is the analytical standard of Ro 08-2750 (HY-108466). This product is intended for research and analytical applications. Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA . Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM .
Cat. No.: HY-180188
Target:
Research Areas:
F1-ispinesib is a heterobifunctional F1-autophagy degrader, composed of an RNA-binding fragment (F1) and the LC3B ligand Ispinesib (HY-50759). F1-ispinesib induces degradation of COL15A1 mRNA via an LC3B-dependent macroautophagy mechanism. F1-ispinesib inhibits cell proliferation and enhances migration of human aortic smooth muscle cells .
Cat. No.: HY-P82159
Synonyms: ILF3; DRBF; MPHOSPH4; NF90; Interleukin enhancer-binding factor 3; Double-stranded RNA-binding protein 76; DRBP76; M-phase phosphoprotein 4; MPP4; Nuclear factor associated with dsRNA; NFAR; Nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80
Cat. No.: HY-187350
Research Areas:
LRPPRC-IN-1 is a LRPPRC inhibitor. LRPPRC-IN-1 exerts dual effects of inhibiting LRPPRC activity and inducing its degradation by binding to the RNA-binding domain of LRPPRC. LRPPRC-IN-1 downregulates the expression of mitochondrial OXPHOS complex subunits and ATP synthase, inhibits oxidative phosphorylation, reduces ATP production, suppresses the proliferation and colony formation of various cancer cells, and inhibits tumor growth in vivo. LRPPRC-IN-1 can be used in studies related to lung cancer, pancreatic cancer, breast cancer, esophageal cancer, colorectal cancer, lymphoma, melanoma, cervical cancer, ovarian cancer, and prostate cancer .
Cat. No.: HY-P82776A
Synonyms: cleft lip and palate transmembrane protein 1
Cat. No.: HY-P702576
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YTHDF2; YTH N6-Methyladenosine RNA binding Protein F2; HGRG8; NY-REN-2; CAHL; YTH N(6)-Methyladenosine RNA binding Protein 2; YTH N6-Methyladenosine RNA binding Protein 2; YTH Domain-Containing Family Protein 2; High-Glucose-Regulated Protein 8; Renal Car
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
